SUSTAINED-RELEASE ISRADIPINE COMPARED WITH SPIRAPRIL IN THE TREATMENT OF ELDERLY PATIENTS WITH ISOLATED SYSTOLIC HYPERTENSION

被引：14
|
作者：
TOMLINSON, B
WOO, J
CRITCHLEY, JAJH
OR, KKH
CHAN, TYK
SANDERSON, JE
机构：
[1] Departments of Clinical Pharmacology (BT, JAJHC, TYKC), Medicine (JW, KKHO, JES), The Chinese University of Hong Kong, Shatin, New Territories
来源：
AMERICAN JOURNAL OF HYPERTENSION | 1994年 / 7卷 / 07期
关键词：
ISRADIPINE; SPIRAPRIL; ISOLATED SYSTOLIC HYPERTENSION;
D O I：
10.1093/ajh/7.7.35S
中图分类号：
R6 [外科学];
学科分类号：
1002 ; 100210 ;
摘要：
The benefits of treating isolated systolic hypertension (ISH) have been established, but the most appropriate choice of drug is still uncertain. For this reason, a sustained-release formulation of isradipine was compared with spirapril in a double-blind randomized study in elderly Chinese patients with ISH. The dosage was titrated if necessary after 4 weeks of treatment. The reduction in systolic/diastolic blood pressure after 8 weeks was similar for both treatments-20/10 mm Hg with isradipine versus 24/6 mm Hg with spirapril-measured in the supine position. There were no orthostatic symptoms and both treatments were well tolerated.
引用
收藏
页码：S35 / S39
页数：5
相关论文
共 50 条
  • [1] Sustained-release isosorbide mononitrate as adjuvant treatment in isolated systolic hypertension in the elderly
    Daniel Abad Pérez
    Iluminada García Polo
    Francisco José Rodríguez Salvanés
    Sara Bellisco Roncal
    Patricia Ibáñez Sanz
    Carmen Suárez Fernández
    Journal of Human Hypertension, 2022, 36 : 163 - 170
  • [2] Sustained-release isosorbide mononitrate as adjuvant treatment in isolated systolic hypertension in the elderly
    Abad Perez, Daniel
    Garcia Polo, Iluminada
    Rodriguez Salvanes, Francisco Jose
    Bellisco Roncal, Sara
    Ibanez Sanz, Patricia
    Suarez Fernandez, Carmen
    JOURNAL OF HUMAN HYPERTENSION, 2022, 36 (02) : 163 - 170
  • [3] ISRADIPINE SUSTAINED-RELEASE ONCE DAILY IN THE TREATMENT OF MILD HYPERTENSION IN THE ELDERLY
    CARRETTA, R
    VRAN, F
    MAZZOLA, C
    VACCARELLA, A
    PACIARONI, E
    FERRONI, C
    MILANI, M
    CURRENT THERAPEUTIC RESEARCH-CLINICAL AND EXPERIMENTAL, 1992, 51 (02): : 281 - 287
  • [4] ANTIHYPERTENSIVE EFFECT OF SUSTAINED-RELEASE ISOSORBIDE DINITRATE FOR ISOLATED SYSTOLIC SYSTEMIC HYPERTENSION IN THE ELDERLY
    DUCHIER, J
    IANNASCOLI, F
    SAFAR, M
    AMERICAN JOURNAL OF CARDIOLOGY, 1987, 60 (01): : 99 - 102
  • [5] EFFICACY AND TOLERANCE OF ISRADIPINE AND SUSTAINED-RELEASE NIFEDIPINE IN THE MANAGEMENT OF HYPERTENSION
    SORET, P
    LUSCHER, TF
    WAEBER, B
    CURRENT THERAPEUTIC RESEARCH-CLINICAL AND EXPERIMENTAL, 1991, 49 (04): : 627 - 634
  • [6] DILEVALOL IS COMPARABLE TO VERAPAMIL SUSTAINED-RELEASE IN THE TREATMENT OF HYPERTENSION IN THE ELDERLY
    WRIGHT, J
    DIETZ, A
    GRAY, J
    KAIHLANEN, P
    CIRANGLE, L
    CLINICAL RESEARCH, 1990, 38 (02): : A544 - A544
  • [7] TREATMENT OF ISOLATED SYSTOLIC HYPERTENSION IN ELDERLY PATIENTS
    DOMINIAK, P
    WEIDINGER, G
    MEDIZINISCHE KLINIK, 1983, 78 (17) : 536 - 539
  • [8] Quadropril (spirapril) in the treatment of isolated Systolic hypertension in patients with type 2 diabetes Mellitus
    Trusov, V. V.
    Filimonov, M. A.
    Aksenov, K. V.
    KARDIOLOGIYA, 2006, 46 (07) : 52 - 54
  • [9] THE NIFEDIPINE GASTROINTESTINAL THERAPEUTIC SYSTEM IN THE TREATMENT OF HYPERTENSION COMPARED WITH PROPRANOL SUSTAINED-RELEASE
    不详
    TGO-TIJDSCHRIFT VOOR THERAPIE GENEESMIDDEL EN ONDERZOEK JDR-JOURNAL FOR DRUGTHERAPY AND RESEARCH, 1992, 17 : 24 - 27
  • [10] Antihypertensive Treatment of Elderly Patients With Isolated Systolic Hypertension
    Uzunyan, T. H.
    Boroyan, R. G.
    Zelveian, P. A.
    KARDIOLOGIYA, 2008, 48 (12) : 59 - 64
12345