A VECTOR DRIVING THE EXPRESSION OF FOREIGN CDNAS IN THE MHC CLASS II-POSITIVE CELLS OF TRANSGENIC MICE

被引：73

作者：

KOUSKOFF, V ^{[1
]}

FEHLING, HJ ^{[1
]}

LEMEUR, M ^{[1
]}

BENOIST, C ^{[1
]}

MATHIS, D ^{[1
]}

机构：

[1] FAC MED STRASBOURG, INST CHIM BIOL,CNRS,GENET MOLEC EUCARYOTES LAB, DOI,INSERM, F-67085 STRASBOURG, FRANCE

来源：

JOURNAL OF IMMUNOLOGICAL METHODS | 1993年 / 166卷 / 02期

关键词：

TRANSGENIC MOUSE; VECTOR; MAJOR HISTOCOMPATIBILITY COMPLEX;

D O I：

10.1016/0022-1759(93)90370-M

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

We describe a plasmid vector that drives the expression of foreign cDNAs in transgenic mice, according to the dictates of an MHC class II gene promoter. Using this vector, we have often obtained mRNA and protein synthesis with a tissue and cell-type specificity indistinguishable from that of the endogenous MHC class II genes.

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页码：287 / 291

页数：5

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