EFFECTS OF LEAD ON KINETICS OF H-3 DOPAMINE UPTAKE BY RAT-BRAIN SYNAPTOSOMES

被引：7
|
作者：
BOYKIN, MJ
CHETTY, CS
RAJANNA, B
机构：
[1] Division of Natural Sciences, Selma University, Selma
来源：
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY | 1991年 / 22卷 / 01期
关键词：
D O I：
10.1016/0147-6513(91)90050-Y
中图分类号：
X [环境科学、安全科学];
学科分类号：
08 ; 0830 ;
摘要：
The effects of lead on 3H-dopamine (3H-DA) uptake in rat brain synaptosomes were studied. Pb inhibited 3H-DA uptake in vitro and in vivo in a concentration-dependent manner. Altered pH versus 3H-DA uptake demonstrated comparable inhibition in buffered acidic, neutral, and alkaline pH ranges, and higher inhibition was observed in neutral pH. Kinetic studies of ATP activation of 3H-DA uptake indicated competitive inhibition by Pb. The inhibition of 3H-DA uptake followed the Na+ concentrations. The results indicate that the Pb inhibition of 3H-DA uptake is pH, ATP, and Na+ dependent. © 1991.
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收藏
页码：88 / 93
页数：6
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