CHANGES IN THE LOW-DENSITY-LIPOPROTEIN PROFILE DURING 17-BETA-ESTRADIOL DYDROGESTERONE THERAPY IN POSTMENOPAUSAL WOMEN

被引：40
作者：
VANDERMOOREN, MJ
DEGRAAF, J
DEMACKER, PNM
DEHAAN, AFJ
ROLLAND, R
机构：
[1] UNIV NIJMEGEN ST RADBOUD HOSP, DEPT OBSTET & GYNECOL, 6500 HB NIJMEGEN, NETHERLANDS
[2] UNIV NIJMEGEN ST RADBOUD HOSP, DEPT GEN INTERNAL MED, 6500 HB NIJMEGEN, NETHERLANDS
[3] UNIV NIJMEGEN ST RADBOUD HOSP, DEPT MED STAT, 6500 HB NIJMEGEN, NETHERLANDS
来源：
METABOLISM-CLINICAL AND EXPERIMENTAL | 1994年 / 43卷 / 07期
关键词：
D O I：
10.1016/0026-0495(94)90256-9
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Changes in the low-density lipoprotein (LDL) subfractions, determined with gradient gel electrophoresis (GGE), were prospectively studied during hormone replacement therapy (HRT) in 23 healthy nonhysterectomized postmenopausal women. LDL subfractions were analyzed by densitometric scanning of the gels. We observed significant changes in the LDL subfraction profile toward a smaller particle size (P < .001). These changes could almost completely be attributed to the hormonal treatment regimen (P < .01), and may indicate an effect partially opposite to the other reported changes in the lipid profile. © 1994.
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页码：799 / 802
页数：4
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