THERMOANALYSIS OF MICROSPHERES

被引：122

作者：

DUBERNET, C

机构：

[1] Laboratoire de Physico-chimie - Pharmacotechnie - Biopharmacie, URA CNRS 1218, F92296 Châtenay-Malabry Cedex

来源：

THERMOCHIMICA ACTA | 1995年 / 248卷

关键词：

DRUG; DSC; GLASS TRANSITION; MICROSPHERE; TGA;

D O I：

10.1016/0040-6031(94)01947-F

中图分类号：

O414.1 [热力学];

学科分类号：

摘要：

This paper describes different cases in which using DSC allows us to obtain more information about the internal structure of microspheres, especially concerning the nature of the interaction between the polymer matrix and the encapsulated drug. A rapid survey of the processes involved in the manufacture of microspheres points to situations in which thermal analysis is able to provide interesting information.

引用

页码：259 / 269

页数：11

共 23 条

[1]

BARKAI A, DRUG DEV IND PHARM, V16, P2057

[2]

BENOIT J, 1986, 13TH P INT S CONTR R, P171

[3] A PHYSICOCHEMICAL STUDY OF THE MORPHOLOGY OF PROGESTERONE-LOADED POLY (D,L-LACTIDE) MICROSPHERES [J].

BENOIT, JP ;

COURTEILLE, F ;

THIES, C .

INTERNATIONAL JOURNAL OF PHARMACEUTICS, 1986, 29 (2-3) :95-102

[4]

BENOIT JP, 1985, 12TH P INT S CONTR R, P27

[5]

Benoit JP, 1984, MICROSPHERES DRUG TH

[6]

Bissery M. C., 1983, 3RD P INT C TECHN PH, V3, P233

[7] PREPARATION AND CHARACTERIZATION OF MICROOSPHERES CONTAINING THE ANTI-INFLAMMATORY AGENTS, INDOMETHACIN, IBUPROFEN, AND KETOPROFEN [J].

BODMEIER, R ;

CHEN, H .

JOURNAL OF CONTROLLED RELEASE, 1989, 10 (02) :167-175

[8] THE EFFECT OF THE ADDITION OF LOW-MOLECULAR WEIGHT POLY(DL-LACTIDE) ON DRUG RELEASE FROM BIODEGRADABLE POLY(DL-LACTIDE) DRUG DELIVERY SYSTEMS [J].

BODMEIER, R ;

OH, KH ;

CHEN, H .

INTERNATIONAL JOURNAL OF PHARMACEUTICS, 1989, 51 (01) :1-8

[9] PREPARATION OF BIODEGRADABLE POLY (+/-) LACTIDE MICROPARTICLES USING A SPRAY-DRYING TECHNIQUE [J].

BODMEIER, R ;

CHEN, HG .

JOURNAL OF PHARMACY AND PHARMACOLOGY, 1988, 40 (11) :754-757

[10] THE FORMATION AND CHARACTERIZATION OF HYDROCORTISONE-LOADED POLY((+/-)-LACTIDE) MICROSPHERES [J].

CAVALIER, M ;

BENOIT, JP ;

THIES, C .

JOURNAL OF PHARMACY AND PHARMACOLOGY, 1986, 38 (04) :249-253

← 1 2 3 →