EFFECTS OF DL-2-BROMOPALMITOYL-COA AND BROMOACETYL-COA IN RAT-LIVER AND HEART-MITOCHONDRIA - INHIBITION OF CARNITINE PALMITOYLTRANSFERASE AND DISPLACEMENT OF [C-14] MALONYL-COA FROM MITOCHONDRIAL BINDING-SITES

被引：26
作者：
EDWARDS, MR [1 ]
BIRD, MI [1 ]
SAGGERSON, ED [1 ]
机构：
[1] UNIV LONDON UNIV COLL,DEPT BIOCHEM,GOWER ST,LONDON WC1E 6BT,ENGLAND
来源：
BIOCHEMICAL JOURNAL | 1985年 / 230卷 / 01期
关键词：
D O I：
10.1042/bj2300169
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
引用
收藏
页码：169 / 179
页数：11
相关论文
共 35 条
[1]   BRAIN ACYL-COENZYME A HYDROLASE - DISTRIBUTION, PURIFICATION AND PROPERTIES [J].
ANDERSON, AD ;
ERWIN, VG .
JOURNAL OF NEUROCHEMISTRY, 1971, 18 (07) :1179-+
[2]   INTERACTING EFFECTS OF L-CARNITINE AND MALONYL-COA ON RAT-LIVER CARNITINE PALMITOYLTRANSFERASE [J].
BIRD, MI ;
SAGGERSON, ED .
BIOCHEMICAL JOURNAL, 1985, 230 (01) :161-167
[3]   CARNITINE ACYLTRANSFERASE ACTIVITIES IN RAT-BRAIN MITOCHONDRIA - BIMODAL DISTRIBUTION, KINETIC CONSTANTS, REGULATION BY MALONYL-COA AND DEVELOPMENTAL PATTERN [J].
BIRD, MI ;
MUNDAY, LA ;
SAGGERSON, ED ;
CLARK, JB .
BIOCHEMICAL JOURNAL, 1985, 226 (01) :323-330
[4]   BINDING OF MALONYL-COA TO ISOLATED-MITOCHONDRIA - EVIDENCE FOR HIGH-AFFINITY AND LOW-AFFINITY SITES IN LIVER AND HEART AND RELATIONSHIP TO INHIBITION OF CARNITINE PALMITOYLTRANSFERASE ACTIVITY [J].
BIRD, MI ;
SAGGERSON, ED .
BIOCHEMICAL JOURNAL, 1984, 222 (03) :639-647
[5]  
BURGES RA, 1968, BIOCHEM J, V109, pP38
[6]   SPECIFIC INHIBITION OF MITOCHONDRIAL FATTY-ACID OXIDATION BY 2-BROMOPALMITATE AND ITS COENZYME-A AND CARNITINE ESTERS [J].
CHASE, JFA ;
TUBBS, PK .
BIOCHEMICAL JOURNAL, 1972, 129 (01) :55-&
[7]   CONDITIONS FOR SELF-CATALYSED INACTIVATION OF CARNITINE ACETYLTRANSFERASE - A NOVEL FORM OF ENZYME INHIBITION [J].
CHASE, JFA ;
TUBBS, PK .
BIOCHEMICAL JOURNAL, 1969, 111 (02) :225-&
[8]  
CHENG Y, 1973, BIOCHEM PHARMACOL, V22, P3099
[9]  
CHOI YR, 1977, J BIOL CHEM, V252, P7930
[10]  
CLARKE PRH, 1981, J BIOL CHEM, V256, P9861
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