ENANTIOSELECTIVE ESTERIFICATION OF 2-METHYLBUTYRIC ACID-CATALYZED VIA LIPASE IMMOBILIZED IN MICROEMULSION-BASED ORGANOGELS

被引：16

作者：

UEMASU, I ^{[1
]}

HINZE, WL ^{[1
]}

机构：

[1] WAKE FOREST UNIV,DEPT CHEM,WINSTON SALEM,NC 27109

来源：

CHIRALITY | 1994年 / 6卷 / 08期

关键词：

ORGANOGELS; REVERSED MICELLES; AEROSOL-OT; LIPASE; 2-METHYLBUTYRIC ACID; ETHYL-2-METHYLBUTYRATE; ENANTIOSELECTIVE REACTION RESOLUTION;

D O I：

10.1002/chir.530060808

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Chromobacterium viscosun lipase (c.v. lipase) was immobilized in microemulsion-based organogels and successfully utilized for the enantioselective esterification of (+/-)-2-methylbutynic acid to preferentially form ethyl-(+)-2-methylbutyrate. The reaction time course and enantioselectivity obtained with the organogel-lipase system was compared and contrasted to that achieved in a reversed micellar solution system that contained lipase solubilized in its inner water core as well as that in which powdered lipases were directly dispersed in an organic solvent. The unique properties and potential benefits of the organogel system are discussed. (C) 1994 Wiley-Liss, Inc.

引用

页码：649 / 653

页数：5

共 27 条

[1]

AKIYAMA A, 1988, CHEMTECH, P627

[2] STRUCTURE AND STABILITY OF MICROEMULSION-BASED ORGANO-GELS [J].