EFFECTS OF PREGANGLIONIC SYMPATHECTOMY ON PEPTIDES IN THE RAT SUPERIOR CERVICAL-GANGLION

被引：14

作者：

DAGERLIND, A ^{[1
]}

ZHANG, X ^{[1
]}

BRIMIJOIN, S ^{[1
]}

LINDH, B ^{[1
]}

HOKFELT, T ^{[1
]}

机构：

[1] MAYO CLIN & MAYO FDN,DEPT PHARMACOL,ROCHESTER,MN

来源：

NEUROREPORT | 1994年 / 5卷 / 08期

关键词：

ACETYLCHOLINESTERASE; CALCITONIN GENE-RELATED PEPTIDE; DEAFFERENTATION; ENKEPHALIN; GALANIN; MESSAGE-ASSOCIATED PEPTIDE; IMMUNOHISTOCHEMISTRY;

D O I：

10.1097/00001756-199404000-00014

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

A novel method to selectively lesion preganglionic sympathetic neurones has been combined with immunohistochemistry to study the expression of peptides in the rat superior cervical ganglion (SCG). Thus, systemic administration of monoclonal antibodies against acteylcholinesterase (AChE) caused a marked reduction in the number of enkephalin (ENK)-positive fibres and a total disappearance of fibres immunoreactive for calcitonin gene-related peptide (CGRP) and AChE in the SCG. A marked increase in the number of galanin/galanin message-associated peptide (GAL/GMAP)-immunoreactive cell bodies was also observed. The present results indicate that probably all CGRP and most ENK containing fibres in the rat SCG are of preganglionic origin and that peptides not normally expressed in SCG neurones, e.g. GAL and GMAP, can be upregulated after deafferentation.

引用

页码：909 / 912

页数：4

共 22 条

[1] THE MORPHOLOGY AND DISTRIBUTION OF NEURONS CONTAINING CHOLINE-ACETYLTRANSFERASE IN THE ADULT-RAT SPINAL-CORD - AN IMMUNOCYTOCHEMICAL STUDY [J].