FARNESYL DIPHOSPHATE SYNTHASE REACTIONS WITH DIMETHYLALLYL DIPHOSPHATE ANALOGS HAVING OXYGEN-ATOMS IN THEIR CHAINS

被引:11
|
作者
MAKI, Y [1 ]
KURIHARA, M [1 ]
ENDO, T [1 ]
ABIKO, M [1 ]
SAITO, K [1 ]
WATANABE, G [1 ]
OGURA, K [1 ]
机构
[1] TOHOKU UNIV, INST CHEM REACT SCI, SENDAI, MIYAGI 980, JAPAN
关键词
D O I
10.1246/cl.1995.389
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
Six dimethylallyl diphosphate analogues having oxygen atoms in their alkyl chains were found to act as substrate in the reaction catalyzed by pig liver farnesyl diphosphate synthase to give geranyl diphosphate analogues or farnesyl diphosphate analogues. The number of IPP incorporated into the product depended on not only the length of the chain but also its hydrophobicity.
引用
收藏
页码:389 / 390
页数:2
相关论文
共 50 条
  • [31] Suppression of phenotype of Escherichia coli mutant defective in farnesyl diphosphate synthase by overexpression of gene for octaprenyl diphosphate synthase
    Takahashi, Hiroshi
    Aihara, Yuta
    Ogawa, Yukihiro
    Murata, Yoshimitsu
    Nakajima, Ken-ichi
    Iida, Maiko
    Shirai, Miyako
    Fujisaki, Shingo
    BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY, 2018, 82 (06) : 1003 - 1010
  • [32] Conversion from archaeal geranylgeranyl diphosphate synthase to farnesyl diphosphate synthase - Two amino acids before the first aspartate-rich motif solely determine eukaryotic farnesyl diphosphate synthase activity
    Ohnuma, S
    Hirooka, K
    Ohto, C
    Nishino, T
    JOURNAL OF BIOLOGICAL CHEMISTRY, 1997, 272 (08) : 5192 - 5198
  • [33] Analogs of farnesyl diphosphate alter CaaX substrate specificity and reactions rates of protein farnesyltransferase
    Jennings, Benjamin C.
    Danowitz, Amy M.
    Wang, Yen-Chih
    Gibbs, Richard A.
    Distefano, Mark D.
    Fierke, Carol A.
    BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2016, 26 (04) : 1333 - 1336
  • [34] Cloning and characterization of bifunctional enzyme farnesyl diphosphate/geranylgeranyl diphosphate synthase from Plasmodium falciparum
    Fabiana M Jordão
    Heloisa B Gabriel
    João MP Alves
    Claudia B Angeli
    Thaís D Bifano
    Ardala Breda
    Mauro F de Azevedo
    Luiz A Basso
    Gerhard Wunderlich
    Emilia A Kimura
    Alejandro M Katzin
    Malaria Journal, 12
  • [35] Cloning and characterization of bifunctional enzyme farnesyl diphosphate/geranylgeranyl diphosphate synthase from Plasmodium falciparum
    Jordao, Fabiana M.
    Gabriel, Heloisa B.
    Alves, Joao M. P.
    Angeli, Claudia B.
    Bifano, Thais D.
    Breda, Ardala
    de Azevedo, Mauro F.
    Basso, Luiz A.
    Wunderlich, Gerhard
    Kimura, Emilia A.
    Katzin, Alejandro M.
    MALARIA JOURNAL, 2013, 12
  • [36] Temperature-dependent modulation of farnesyl diphosphate/geranylgeranyl diphosphate synthase from hyperthermophilic archaea
    Fujiwara, S
    Yamanaka, A
    Hirooka, K
    Kobayashi, A
    Imanaka, T
    Fukusaki, EI
    BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2004, 325 (03) : 1066 - 1074
  • [37] Aromatic and 7-substituted farnesyl diphosphate analogs.
    Guo, ZM
    Zhou, CM
    Shao, Y
    Gibbs, RA
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2000, 219 : U11 - U11
  • [38] Molecular cloning and tissue expression of an insect farnesyl diphosphate synthase
    Castillo-Gracia, M
    Couillaud, F
    EUROPEAN JOURNAL OF BIOCHEMISTRY, 1999, 262 (02): : 365 - 370
  • [39] Synthesis and Enzymatic Studies of Bisubstrate Analogues for Farnesyl Diphosphate Synthase
    Ramamoorthy, Gurusankar
    Pugh, Mark L.
    Tian, Bo-Xue
    Phan, Richard M.
    Perez, Lawrence B.
    Jacobson, Matthew P.
    Poulter, C. Dale
    JOURNAL OF ORGANIC CHEMISTRY, 2015, 80 (08): : 3902 - 3913
  • [40] ISOLATION AND CHARACTERIZATION OF AN ESCHERICHIA-COLI MUTANT HAVING TEMPERATURE-SENSITIVE FARNESYL DIPHOSPHATE SYNTHASE
    FUJISAKI, S
    NISHINO, T
    KATSUKI, H
    HARA, H
    NISHIMURA, Y
    HIROTA, Y
    JOURNAL OF BACTERIOLOGY, 1989, 171 (10) : 5654 - 5658