TOBACCO MOSAIC-VIRUS - A MODEL ANTIGEN TO STUDY VIRUS-ANTIBODY INTERACTIONS

被引：10

作者：

VANREGENMORTEL, MHV

ALTSCHUH, D

ZEDERLUTZ, G

机构：

[1] Laboratoire d'Immunochimie, Institut de Biologie Moléculaire et Cellulaire, CNRS, 67084 Strasbourg Cedex, 15, rue René Descartes

来源：

BIOCHIMIE | 1993年 / 75卷 / 08期

关键词：

TOBACCO MOSAIC VIRUS; ANTIGENICITY OF VIRUSES; ANTIBODY AFFINITY CONSTANT; MONOCLONAL ANTIBODIES TO VIRUSES; KINETICS OF ANTIBODY BINDING; IMMUNOCHEMISTRY OF VIRUSES;

D O I：

10.1016/0300-9084(93)90104-Z

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

For more than 50 years, tobacco mosaic virus (TMV) has been used as a model system for studying various aspects of virus-antibody interactions. Distinct epitopes called neotopes and cryptotopes have been identified in intact TMV particles and dissociated viral protein respectively and a correlation has been found to exist between the location of continuous epitopes and the extent of segmental mobility along the viral polypeptide chain. The occurrence of bivalent antibody binding was shown to influence the observed affinity of TMV antibodies and kinetic measurements of antibody binding to viral peptides made it possible to analyze the mechanism of binding of monoclonal antibodies. It seems likely that the TMV model will continue to yield a rich harvest of immunochemical data relevant to many viral systems.

引用

页码：731 / 739

页数：9

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