N-ACETYLCYSTEINE PROTECTS AGAINST AGE-RELATED DECLINE OF OXIDATIVE-PHOSPHORYLATION IN LIVER-MITOCHONDRIA

被引：72
作者：
MIQUEL, J
FERRANDIZ, ML
DEJUAN, E
SEVILA, I
MARTINEZ, M
机构：
[1] UNIV ALICANTE, FAC MED, INST NEUROSCI, E-03080 ALACANT, SPAIN
[2] UNIV VALENCIA, FAC FARM, DEPT FARMACOL, E-46010 VALENCIA, SPAIN
来源：
EUROPEAN JOURNAL OF PHARMACOLOGY-ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY SECTION | 1995年 / 292卷 / 3-4期
关键词：
AGING; MITOCHONDRIA; N-ACETYLCYSTEINE; THIOL;
D O I：
10.1016/0926-6917(95)90041-1
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Since it has been proposed that oxygen radical inactivation of key enzymes plays a critical role in cell aging, we have investigated the effects of a thiolic free radical scavenger on the oxidative phosphorylation enzymes of liver mitochondria from female OF-1 mice. At 48 weeks of age a control group was fed standard food pellets and another group received pellets containing 0.3% (w/w) of N-acetylcysteine. A 24-week treatment resulted in a significant increase in the specific activities of complex I, IV and V in the hepatic mitochondria of the N-acetylcysteine-treated animals as compared to aged controls.
引用
收藏
页码：333 / 335
页数：3
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