HLA-B8,DR3 PHENOTYPE AND THE ANTIBODY-RESPONSE AGAINST EPSTEIN-BARR-VIRUS

被引：6
作者：
CARUSO, C [1 ]
CANDORE, G [1 ]
COLUCCI, AT [1 ]
CIGNA, D [1 ]
SAMMARTANO, F [1 ]
AMMATUNA, P [1 ]
机构：
[1] UNIV PALERMO,DIPARTIMENTO IGIENE & MICROBIOL,I-90134 PALERMO,ITALY
来源：
IMMUNOLOGICAL INVESTIGATIONS | 1993年 / 22卷 / 01期
关键词：
D O I：
10.3109/08820139309066192
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Antibodies against the viral capsid antigen (VCA) and nuclear antigens (EBNAs) of the Epstein-Barr virus (EBV) were determined in a sample of Sicilian population. A significant correlation was observed between HLA-BB,DR3 phenotype and reduced titres of antibodies to EBNAs, whereas HLA-BB,DR3 positive individuals displayed levels of antibodies to VCA comparable to those of HLA-BB,DR3 negative ones. These results further strenghten the suggestion that HLA-BB,DR3 positive subjects are low responders and that the depth of immune response depends on on the fashion of antigenic challenge.
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页码：41 / 51
页数：11
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