ANTIOXIDANT ACTIVITY OF DIBENZOCYCLOOCTENE LIGNANS ISOLATED FROM SCHISANDRACEAE

被引：169

作者：

LU, H ^{[1
]}

LIU, GT ^{[1
]}

机构：

[1] CHINESE ACAD MED SCI,INST MAT MED,DEPT PHARMACOL,BEIJING 100050,PEOPLES R CHINA

来源：

PLANTA MEDICA | 1992年 / 58卷 / 04期

关键词：

SCHISANDRA-CHINENSIS; SCHISANDRA-RUBRIFLORA; KADSURA-LONGIPEDUNCULATA; DIBENZOCYCLOOCTENE LIGNANS; SCHISANHENOL; LIPID PEROXIDATION; ANTIOXIDANT ACTIVITY;

D O I：

10.1055/s-2006-961473

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

The anti-oxidant activity of nine dibenzocyclooctene lignans isolated from Schisandra chinensis, S. rubriflora, and Kadsura longipedunculata, respectively, was studied. Seven of the 9 lignans (1 mM) inhibited iron/cysteine-induced lipid peroxidation (malondialdehyde, MDA, formation) of rat liver microsomes as well as superoxide anion production in the xanthine/xanthine oxidase system. The actions of the 7 lignans were much more potent than vitamin E at the same concentration of 1 mM. Among the lignans, schisanhenol was the most active one. This compound also prevented the decrease of membrane fluidity of liver microsomes induced by iron/cysteine. The results indicated that seven of the lignans such as schisanhenol have anti-oxidant activities.

引用

页码：311 / 313

页数：3

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