Local drug delivery to the bone by drug-releasing implants: perspectives of nano-engineered titania nanotube arrays

被引：100
|
作者：
Gulati, Karan [1 ]
Aw, Moom Sinn [1 ]
Findlay, David [2 ]
Losic, Dusan [1 ]
机构：
[1] Univ Adelaide, Sch Chem Engn, N119 North Engn Bldg, Adelaide, SA 5005, Australia
[2] Univ Adelaide, Discipline Orthopaed & Trauma, Adelaide, SA 5005, Australia
来源：
THERAPEUTIC DELIVERY | 2012年 / 3卷 / 07期
基金：
澳大利亚研究理事会;
关键词：
D O I：
10.4155/TDE.12.66
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Titania nanotube (TNT) arrays fabricated by electrochemical anodization of titanium are currently one of the most attractive nanomaterials due to their remarkable properties. In this review, we highlight recent research activities that are focused on the application of the TNT arrays for local drug delivery, specifically for addressing problems associated with orthopedic implants. The advantages of drug-releasing implants based on TNT arrays for local delivery of therapeutics in bone related to these challenging problems including inflammation, infection and osseointegration are discussed. An overview of recent research to advance the drug-releasing performance of TNT arrays and the potential of their future applications and development are presented.
引用
收藏
页码：857 / 873
页数：17
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