GANGLIOSIDE G(D1A) GENERATES DOMAINS OF HIGH CURVATURE IN PHOSPHATIDYLETHANOLAMINE LIPOSOMES AS DETERMINED BY SOLID-STATE P-31-NMR SPECTROSCOPY

被引：19

作者：

VANGORKOM, LCM ^{[1
]}

CHEETHAM, JJ ^{[1
]}

EPAND, RM ^{[1
]}

机构：

[1] MCMASTER UNIV,HLTH SCI CTR,DEPT BIOCHEM,HAMILTON,ON L8N 3Z5,CANADA

来源：

CHEMISTRY AND PHYSICS OF LIPIDS | 1995年 / 76卷 / 01期

关键词：

ISOTROPIC PHASE; INVERTED PHASES; BILAYER DEFECTS;

D O I：

10.1016/0009-3084(95)02419-J

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

We have studied the effects of gangliosides on the polymorphic behaviour of phosphatidylethanolamines. The ganglioside G(D1a) promotes the formation of phases which give rise to isotropic P-31-NMR resonance lines, particularly in the temperature range of the L(alpha) to H-II transition, In addition, higher mol fractions of ganglioside raise the L(alpha) to H-II phase transition temperature. Our results demonstrate that small mol fractions of gangliosides can have profound effects on the molecular organization of phosphatidylethanolamines.

引用

页码：103 / 108

页数：6

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