AN APPROACH TO THE SYNTHESIS OF ENANTIOMERICALLY PURE HYDROXYLATED ALPHA-AMINO-ACIDS USING ZINC HOMOENOLATE CHEMISTRY

被引：0

作者：

JACKSON, RFW ^{[1
]}

WOOD, A ^{[1
]}

WYTHES, MJ ^{[1
]}

机构：

[1] PFIZER LTD,SANDWICH CT13 9NJ,KENT,ENGLAND

来源：

SYNLETT | 1990年 / 12期

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D O I：

暂无

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Diastereoselective reduction of enantiomerically pure 4-oxo alpha-amino acids, available from the reaction of the zinc homoenolate 1 [(S)-N-(tert-butoxycarbonyl)-3-iodozinciolanine benzyl ester] with alpha-functionalised acetyl chlorides in the presence of bis(triphenylphosphine)palladium dichloride, allows the preparation of a variety of 4-hydroxy alpha-amino acid derivatives, including the potential clavalanine precursor 5a and the erythro 4-hydroxyornithine derivative 6f.

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页码：735 / 736

页数：2

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