GENETIC-STUDY OF OXYGEN RESISTANCE AND MELANIZATION IN CRYPTOCOCCUS-NEOFORMANS

被引:25
作者
EMERY, HS
SHELBURNE, CP
BOWMAN, JP
FALLON, PG
SCHULZ, CA
JACOBSON, ES
机构
[1] VET ADM MED CTR,RES SERV 151,RICHMOND,VA 23249
[2] VIRGINIA COMMONWEALTH UNIV,MED COLL VIRGINIA,DEPT INTERNAL MED,RICHMOND,VA 23298
关键词
D O I
10.1128/IAI.62.12.5694-5697.1994
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Genetic analysis of oxygen-sensitive mutants of Cryptococcus neoformans revealed two loci (oxy1 and oxy2) linking hyperoxia sensitivity to production of melanin, a known virulence factor. Hyperoxia-sensitive strain 562 (oxy1 oxy2) is albino and avirulent. oxy2-defective strains lacking the oxy1 defect are melanin deficient but show normal hyperoxia resistance. Mutants defective at three additional mapped melanin loci fail to show hyperoxia sensitivity in the oxy1 background. Revertants of strain 562, which regain the ability to synthesize melanin by mutation at suppressor sites unlinked to oxy2, retain the oxygen sensitivity conferred by their oxy1 and oxy2 defects. These data identify the melanin gene oxy2 as unique in its association of hyperoxia resistance and melanization.
引用
收藏
页码:5694 / 5697
页数:4
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