CONTRIBUTION OF 5-HT1A SEROTONIN RECEPTORS OF THE BRAIN TO THE REGULATION OF HEREDITARY CATALEPSY

被引：1

作者：

POPOVA, NK ^{[1
]}

KULIKOV, AV ^{[1
]}

AVGUSTINOVICH, DF ^{[1
]}

VISHNIVETSKAYA, GB ^{[1
]}

KOLPAKOV, VG ^{[1
]}

机构：

[1] RUSSIAN ACAD SCI,INST CYTOL & GENET,DEPT BEHAV PHENOGENET,NOVOSIBIRSK 630090,RUSSIA

来源：

BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE | 1994年 / 118卷 / 12期

关键词：

5-HT1A RECEPTORS; HEREDITARY CATALEPSY; FLEZINOXAN;

D O I：

10.1007/BF02445742

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Selective agonists 5-HT1A of serotonin receptors (8-OH-DPAT and flezinoxan) had an inhibitory effect on the manifestation of hereditary catalepsy in mice and rats. No differences were revealed in specific binding of H-3-8-OH-DPAT to 5-HT1A receptors in the striatum of either cataleptic or noncataleptic mice and rats. Nonetheless, an increase of the density of these receptors was observed in the frontal cortex of CBA mice predisposed to catalepsy in comparison with mice of the noncataleptic C57B1 strain. The data indicate a contribution of 5-HT1A receptors to the regulation of hereditary catalepsy.

引用

页码：1324 / 1327

页数：4

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