SEMICONTINUOUS AFFINITY-CHROMATOGRAPHY SEPARATIONS

被引：4
作者：
MCCOY, BJ
机构：
[1] Univ of California, Davis, Dep of, Chemical Engineering, Davis, CA, USA, Univ of California, Davis, Dep of Chemical Engineering, Davis, CA, USA
来源：
BIOTECHNOLOGY AND BIOENGINEERING | 1985年 / 27卷 / 10期
关键词：
ADSORPTION; -; BIOCHEMISTRY; DESORPTION;
D O I：
10.1002/bit.260271012
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
The semicontinuous operation of affinity chromatography columns charged and eluted alternately is studied mathematically. A strongly nonlinear adsorption equilibrium relation is utilized to examine the periodic mode of adsorption and desorption. The governing differential equations are solved by the method of characteristics. The time interval between desorption and adsorption periods is estimated, and implications for separations are discussed to show the advantages of semicontinuous cyclic operation.
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页码：1477 / 1481
页数：5
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