ON THE MECHANISM OF ARYLAMINE-DNA ADDUCT FORMATION

被引：4
|
作者：
WERBOVETZ, KA [1 ]
MACDONALD, TL [1 ]
机构：
[1] UNIV VIRGINIA,DEPT CHEM,CHARLOTTESVILLE,VA 22901
来源：
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1994年 / 4卷 / 19期
关键词：
D O I：
10.1016/0960-894X(94)85033-X
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
7-Methoxy-9-benzylguanine was converted to a mixture of 8-keto-9-benzylguanine and 8-methoxy-9-benzylguanine upon treatment with aqueous base. This model system highlights the reactivity of a heteroatom-N7 guanyl species (implicated as an intermediate in the mechanism of formation of arylamine-guanine adducts) toward nucleophilic attack at C8.
引用
收藏
页码：2323 / 2326
页数：4
相关论文
共 50 条
  • [41] DNA-cleaving and adduct formation by fullerenes
    Samal, S
    Murthy, CN
    Geckeler, KE
    ADVANCED MACROMOLECULAR AND SUPRAMOLECULAR MATERIALS AND PROCESSES, 2003, : 291 - 307
  • [42] Tamoxifen - DNA adduct formation in human endometrium
    Beland, FA
    Marques, MM
    da Costa, GG
    Phillips, DH
    CHEMICAL RESEARCH IN TOXICOLOGY, 2005, 18 (10) : 1507 - 1509
  • [43] DNA adduct formation by allyl glycidyl ether
    Plna, K
    Segerback, D
    Schweda, EKH
    CARCINOGENESIS, 1996, 17 (07) : 1465 - 1471
  • [44] FORMATION AND PROPERTIES OF THE DNA-ELECTRON ADDUCT
    VERBERNE, JB
    LOMAN, H
    RADIATION AND ENVIRONMENTAL BIOPHYSICS, 1980, 17 (04) : 311 - 311
  • [45] FORMATION OF AN UNSTABLE IQ-DNA ADDUCT
    DRAGSTED, LO
    HANSEN, LL
    AUTRUP, H
    EUROPEAN JOURNAL OF CANCER & CLINICAL ONCOLOGY, 1988, 24 (09): : 1547 - 1547
  • [46] Naphthalene DNA adduct formation and tolerance in the lung
    Buchholz, Bruce A.
    Carratt, Sarah A.
    Kuhn, Edward A.
    Collette, Nicole M.
    Ding, Xinxin
    Van Winkle, Laura S.
    NUCLEAR INSTRUMENTS & METHODS IN PHYSICS RESEARCH SECTION B-BEAM INTERACTIONS WITH MATERIALS AND ATOMS, 2019, 438 : 119 - 123
  • [47] Effect of DNA conformation on cisplatin adduct formation
    Bubley, GJ
    Xu, J
    Kupiec, N
    Sanders, D
    Foss, F
    OBrien, M
    Emi, Y
    Teicher, BA
    Patierno, SR
    BIOCHEMICAL PHARMACOLOGY, 1996, 51 (05) : 717 - 721
  • [48] Switch-on effect on conformation-specific arylamine–DNA adduct by cyclometalated Ir(III) complexes
    David Dayanidhi Paul Elisa
    Vaidyanathan Vaidyanathan Ganesan
    JBIC Journal of Biological Inorganic Chemistry, 2020, 25 : 305 - 310
  • [49] FORMATION OF DNA ADDUCT BY MEIQX - RELATION BETWEEN ADMINISTRATION DOSE AND ADDUCT LEVEL
    HIROSE, M
    TAKAYAMA, K
    WAKABAYASHI, K
    SUGIMURA, T
    NAGAO, M
    MUTATION RESEARCH, 1991, 252 (01): : 89 - 90
  • [50] Synthetic chemistry of the aristolochic acids, DNA adducts, and metabolic products: Comments on the mechanism(s) of DNA-adduct formation
    Johnson, Francis
    Attaluri, Sivaprasad
    Bonala, Radha R.
    Iden, Charles
    Zaitseva, Irina N.
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2012, 244
12345