ON THE MECHANISM OF ARYLAMINE-DNA ADDUCT FORMATION

被引：4
|
作者：
WERBOVETZ, KA [1 ]
MACDONALD, TL [1 ]
机构：
[1] UNIV VIRGINIA,DEPT CHEM,CHARLOTTESVILLE,VA 22901
来源：
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1994年 / 4卷 / 19期
关键词：
D O I：
10.1016/0960-894X(94)85033-X
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
7-Methoxy-9-benzylguanine was converted to a mixture of 8-keto-9-benzylguanine and 8-methoxy-9-benzylguanine upon treatment with aqueous base. This model system highlights the reactivity of a heteroatom-N7 guanyl species (implicated as an intermediate in the mechanism of formation of arylamine-guanine adducts) toward nucleophilic attack at C8.
引用
收藏
页码：2323 / 2326
页数：4
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