ON THE MECHANISM OF ARYLAMINE-DNA ADDUCT FORMATION

被引：4

作者：

WERBOVETZ, KA ^{[1
]}

MACDONALD, TL ^{[1
]}

机构：

[1] UNIV VIRGINIA,DEPT CHEM,CHARLOTTESVILLE,VA 22901

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1994年 / 4卷 / 19期

关键词：

D O I：

10.1016/0960-894X(94)85033-X

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

7-Methoxy-9-benzylguanine was converted to a mixture of 8-keto-9-benzylguanine and 8-methoxy-9-benzylguanine upon treatment with aqueous base. This model system highlights the reactivity of a heteroatom-N7 guanyl species (implicated as an intermediate in the mechanism of formation of arylamine-guanine adducts) toward nucleophilic attack at C8.

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页码：2323 / 2326

页数：4

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