MIF-1 CAN ACCELERATE NEUROMOTOR, EEG AND BEHAVIORAL-DEVELOPMENT IN MICE

被引：16

作者：

DAMORE, A ^{[1
]}

PIERETTI, S ^{[1
]}

PALAZZESI, S ^{[1
]}

PEZZINI, G ^{[1
]}

CHIAROTTI, F ^{[1
]}

SCORZA, T ^{[1
]}

LOIZZO, A ^{[1
]}

机构：

[1] IST SUPER SANITA,VIALE REGINA ELENA 299,I-00161 ROME,ITALY

来源：

PEPTIDES | 1990年 / 11卷 / 03期

关键词：

EEG; Learning; MIF-1; Ontogeny; Prolyl-leucyl-glycinamide (PLG); Reflexes;

D O I：

10.1016/0196-9781(90)90054-9

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Newborn mice were injected SC daily with 1 mg/kg of MIF-1 or saline during the first 19 days of life. The progress of each pup was monitored for physical (body weight, eye and ear opening), neurobehavioral (reflexes) and neurophysiological (EEG) development until the weaning stage. In early adulthood (40 days of age) mice were tested on a maze learning task. Results indicate that MIF-1 can accelerate neurologic (days 3-9), somatic (days 10-14) and electroencephalographic (days 16-19) parameters, and that the effects of treatment last into the early adult stage with increased learning abilities in an appetitive task. © 1990.

引用

页码：527 / 532

页数：6

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