GENOMICS AND PROTEOMICS METHODS AND THEIR VALUE IN BREAST CANCER DIAGNOSIS

被引:0
作者
Atalay, Can [1 ]
机构
[1] Ankara Onkoloji Hastanesi, Genel Cerrahi, Ankara, Turkey
来源
JOURNAL OF BREAST HEALTH | 2010年 / 6卷 / 02期
关键词
cancer; diagnosis; genomics; proteomics;
D O I
暂无
中图分类号
Q [生物科学];
学科分类号
07 ; 0710 ; 09 ;
摘要
Genomics and proteomics are newly developing fields and becoming widely used in cancer research especially in cancer diagnosis. The aim is to review the role of genomics and proteomics to discover new breast cancer biomarkers for diagnosis with higher sensitivity and specificity. Studies reporting on potential biomarkers in breast cancer were included in this review. In the future, platforms in genomics and proteomics will be used for the discovery of tumor specific genes and related proteins, which will lead to development of novel therapeutic targets leading to patient specific therapies.
引用
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页码:47 / 52
页数:6
相关论文
共 25 条
[11]   NEW DESORPTION STRATEGIES FOR THE MASS-SPECTROMETRIC ANALYSIS OF MACROMOLECULES [J].
HUTCHENS, TW ;
YIP, TT .
RAPID COMMUNICATIONS IN MASS SPECTROMETRY, 1993, 7 (07) :576-580
[12]   Tissue microarrays for high-throughput molecular profiling of tumor specimens [J].
Kononen, J ;
Bubendorf, L ;
Kallioniemi, A ;
Bärlund, M ;
Schraml, P ;
Leighton, S ;
Torhorst, J ;
Mihatsch, MJ ;
Sauter, G ;
Kallioniemi, OP .
NATURE MEDICINE, 1998, 4 (07) :844-847
[13]   Independent validation of candidate breast cancer serum biomarkers identified by mass spectrometry [J].
Li, JN ;
Orlandi, R ;
White, CN ;
Rosenzweig, J ;
Zhao, J ;
Seregni, E ;
Morelli, D ;
Yu, YH ;
Meng, XY ;
Zhang, Z ;
Davidson, NE ;
Fung, ET ;
Chan, DW .
CLINICAL CHEMISTRY, 2005, 51 (12) :2229-2235
[14]   Identification of biomarkers for breast cancer in nipple aspiration and ductal lavage fluid [J].
Li, JN ;
Zhao, J ;
Yu, XD ;
Lange, J ;
Kuerer, H ;
Krishnamurthy, S ;
Schilling, E ;
Khan, SA ;
Sukumar, S ;
Chan, DW .
CLINICAL CANCER RESEARCH, 2005, 11 (23) :8312-8320
[15]  
Li JN, 2002, CLIN CHEM, V48, P1296
[16]   Gene expression profiles of human breast cancer progression [J].
Ma, XJ ;
Salunga, R ;
Tuggle, JT ;
Gaudet, J ;
Enright, E ;
McQuary, P ;
Payette, T ;
Pistone, M ;
Stecker, K ;
Zhang, BM ;
Zhou, YX ;
Varnholt, H ;
Smith, B ;
Gadd, M ;
Chatfield, E ;
Kessler, J ;
Baer, TM ;
Erlander, MG ;
Sgroi, DC .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2003, 100 (10) :5974-5979
[17]   Proteomic patterns of nipple aspirate fluids obtained by SELDI-TOF: Potential for new biomarkers to aid in the diagnosis of breast cancer [J].
Paweletz, CP ;
Trock, B ;
Pennanen, M ;
Tsangaris, T ;
Magnant, C ;
Liotta, LA ;
Petricoin, EF .
DISEASE MARKERS, 2001, 17 (04) :301-307
[18]   Significant differences in nipple aspirate fluid protein expression between healthy women and those with breast cancer demonstrated by time-of-flight mass spectrometry [J].
Pawlik, TM ;
Fritsche, H ;
Coombes, KR ;
Xiao, LC ;
Krishnamurthy, S ;
Hunt, KK ;
Pusztai, L ;
Chen, JN ;
Clarke, CH ;
Arun, B ;
Hung, MC ;
Kuerer, HM .
BREAST CANCER RESEARCH AND TREATMENT, 2005, 89 (02) :149-157
[19]   Molecular classification of breast cancer: Limitations and potential [J].
Pusztai, Lajos ;
Mazouni, Chafika ;
Anderson, Keith ;
Wu, Yun ;
Symmans, W. Fraser .
ONCOLOGIST, 2006, 11 (08) :868-877
[20]   Proteomic analysis of nipple aspirate fluid to detect biologic markers of breast cancer [J].
Sauter, ER ;
Zhu, W ;
Fan, XJ ;
Wassell, RP ;
Chervoneva, I ;
Du Bois, GC .
BRITISH JOURNAL OF CANCER, 2002, 86 (09) :1440-1443