Cd40 doesn't Complement The Function Of Epstein-barr Virus (Ebv) Latent Membrane Protein 1 In B Cells Transformation

被引：0

作者：

Nazmul, A. ^{[1
]}

Anwarul, A. A. ^{[1
]}

机构：

[1] Univ Dhaka, Dept Genet Engn & Biotechnol, Dhaka 1000, Bangladesh

来源：

BANGLADESH JOURNAL OF MEDICAL SCIENCE | 2012年 / 11卷 / 02期

关键词：

Epstein-Barr virus; CD40 and CD40L; latent membrane protein; B cell transformation;

D O I：

暂无

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Objective: Epstein-Barr virus (EBV) latent membrane protein 1 (LMP1) is known to plays important role in B cells growth and transformation. LMP1 is considered to be a functional homologue of the CD40 receptor and they can activate many overlapping signaling pathways. In this study, we compared the function of CD40 with that of LMP1 in B cells transformation. Materials and methods: Expression of CD40L was observed in infected B cells with LMP1 mutated EBV. To observe the expression reverse transcription-PCR were performed. Results: This expression of CD40L did not support proliferation and transformation of B cell. Even in vitro proliferation and transformation of B cell infected with LMP1 deleted EBV supplemented with CD40L were also not observed. Conclusion: Despite many similarities shared between CD40 and LMP1, CD40-CD40L interaction didn't complement on LMP1 mediated B cells transformation in vitro.

引用

页码：112 / 116

页数：5

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