EVALUATION OF A VARIABLE DOSE RANITIDINE REGIMEN IN THE TREATMENT OF DUODENAL-ULCER DISEASE

被引：1

作者：

PHILLIPS, J ^{[1
]}

MILLS, JG ^{[1
]}

WOOD, JR ^{[1
]}

机构：

[1] GLAXO GRP RES LTD,DEPT GASTROENTEROL,GREENFORD RD,GREENFORD UB6 0HE,MIDDX,ENGLAND

来源：

EUROPEAN JOURNAL OF GASTROENTEROLOGY & HEPATOLOGY | 1993年 / 5卷 / 05期

关键词：

RANITIDINE; DUODENAL ULCER; CLINICAL TRIAL;

D O I：

10.1097/00042737-199305000-00004

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Objective: This double-blind, randomized, international, multicentre study was undertaken to determine the effect of a variable dose ranitidine regimen (300 mg four times daily for 7 days which was reduced to 300 mg at night for a further 21 days) on symptom relief and duodenal ulcer healing compared with the standard dose ranitidine regimen (300 mg at night for 28 days). Patients: The study included 223 patients with endoscopically-confirmed duodenal ulcers (ulcer diameter greater-than-or-equal-to 5 mm). Results: After 2 weeks of treatment, complete ulcer healing was observed in 64 and 52% of patients for the variable dose and night-time regimens, respectively (P = 0.076). By 4 weeks, cumulative healing rates were 98 and 89%, respectively (P < 0.01). A greater number of patients receiving the variable dose had complete relief from epigastric pain after 2 weeks compared with those on the standard dose (75 compared with 63%). By 4 weeks, 81 and 72% of patients were free from epigastric pain. Analysis of diary cards showed significant differences in the median time to the first pain-free day (2 compared with 5 days; P < 0.001) and complete pain relief (4 compared with 6 days; P < 0.05) between the two regimens, respectively. Conclusion: A higher dose of ranitidine for the first week of therapy can expedite pain relief and increase the frequency of duodenal ulcer healing after 4 weeks of treatment.

引用

页码：319 / 324

页数：6

共 12 条

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