OCCURRENCE, CHARACTERISTICS, AND PATTERNS OF HIV-1 AND HIV-2 WESTERN-BLOT INDETERMINATE SERA IN LOW-RISK POPULATIONS IN WEST-VIRGINIA AND PRE-AIDS AFRICA

被引：12

作者：

SCHINDZIELORZ, AH ^{[1
]}

BELSHE, RB ^{[1
]}

MUFSON, MA ^{[1
]}

机构：

[1] MARSHALL UNIV,SCH MED,HUNTINGTON,WV 25701

来源：

AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE | 1990年 / 42卷 / 05期

关键词：

D O I：

10.4269/ajtmh.1990.42.460

中图分类号：

R1 [预防医学、卫生学];

学科分类号：

1004 ; 120402 ;

摘要：

To further characterize HIV-1 and HIV-2 Western blot indeterminate (IWB) sera, 402 sera from 318 healthy low-risk individuals from West Virginia and 159 African sera obtained in the pre-AIDS era (1968-1972) were studied. All IWB sera tested for antigen by HIV-1 enzyme immunoassay (EIA-Ag) were negative. HIV-1 and HIV-2 IWB reactivity occurred independent of HIV-1 and HIV-2 false-positive testing for antibody by enzyme immunoassay (EIA-Ab) and no cross-reactions between HIV-1 and HIV-2 IWB patterns were detected. The IWB patterns were reproducible, demonstrated no age or sex related pattern, and showed no evidence of vertical or horizontal transmission. The African sera exhibited a significantly higher number of IWB patterns. IWB reactivity in HIV-1 and HIV-2 seronegative individuals may not be viral in origin and the occurrence of IWB pattern may vary among populations.

引用

页码：460 / 464

页数：5

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