RESEARCHES ON THE FLUORESCENT PROPERTIES OF THE (NA+/K+)ATPASE

被引：0
作者：
GRIMALDI, S
POZZI, D
PASCALE, E
DONOFRIO, M
VERNA, R
GIGANTI, G
MONACO, F
ROCHE, J
机构：
[1] UNIV AQUILA, CATTEDRA CHIM, I-67100 AQUILA, ITALY
[2] UNIV AQUILA, MICROSCOPIA CLIN, I-67100 AQUILA, ITALY
[3] CNR, IST MED SPERIMENTALE, ROME, ITALY
[4] UNIV ROME LA SAPIENZA, DIPARTIMENTO MED SPERIMENTALE, I-00185 ROME, ITALY
[5] UNIV ROMA TOR VERGATA, DIPARTIMENTO MED SPERIMENTALE, ROME, ITALY
[6] COLL FRANCE, F-75231 PARIS 05, FRANCE
[7] UNIV CHIETI, CATTEDRA ENDOCRINOL, CHIETI, ITALY
来源：
COMPTES RENDUS DES SEANCES DE LA SOCIETE DE BIOLOGIE ET DE SES FILIALES | 1987年 / 181卷 / 06期
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D O I：
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中图分类号：
Q [生物科学];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
1. The effect of ouabain on the molecular properties of (Na+/K+)-ATPase has been studied in purified preparations of the enzyme, isolated from the microsomal fraction of outer red medulla of porcine kidney, according to a modification of the method described by Jorgensen (1). 2. Ouabain, a specific inhibitor of (Na+/K+)-ATPase, binds at the potassium site of the enzyme, thus generating an increase in its stability towards the common denaturing agents, such as exposure to different concentration of guanidinium chloride (GdmC1) or to acidic solutions.
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页码：609 / 615
页数：7
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