CORRELATIONS OF PERITONEAL INTERLEUKIN-6, SERUM BETA-2-MICROGLOBULIN AND URINARY BETA-2-MICROGLOBULIN AFTER ELECTIVE ABDOMINAL-SURGERY

Postoperative peritoneal interleukin-6 (P-IL-6), serum beta-2 microglobulin (SBMG) and urinary beta-2 microglobulin (UBMG) concentrations were examined in 33 patients who underwent various types of abdominal surgery. Similar time-dependent changes in SBMG and UBMG were observed in five other patients who underwent abdominal surgery. SBMG decreased the first day after the operation (IPOD), then increased and reached the preoperative level by the third day after the operation (3POD). UBMG started to increase IPOD, reached the maximum 3POD, then decreased. The IPOD SBMG concentration was significantly correlated with P-IL-6, and 3POD UBMG was also significantly correlated with P-IL-6. These findings indicate that serum and urinary beta-2 microglobulin concentrations are closely correlated with P-IL-6.