HUMAN PERIPHERAL GAMMA-DELTA-T-CELLS ARE STIMULATED BY DAUDI BURKITTS-LYMPHOMA AND NOT BY ANY OTHER BURKITTS-LYMPHOMA TESTED

被引:19
作者
KAUR, I
DEJONG, J
SCHELL, K
HANK, J
FISCH, P
SONDEL, PM
机构
[1] UNIV WISCONSIN,CTR COMPREHENS CANC,DEPT HUMAN ONCOL,MADISON,WI 53792
[2] UNIV WISCONSIN,DEPT PEDIAT,MADISON,WI 53792
[3] UNIV WISCONSIN,DEPT GENET,MADISON,WI 53792
关键词
D O I
10.1006/cimm.1994.1152
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
Daudi Burkitt's lymphoma cells have molecules on their surface which can stimulate proliferation of human gamma delta T cells, while Raji, another Burkitt's lymphoma, cannot stimulate human gamma delta T cells. Human peripheral gamma delta T cells, coexpressing the V(gamma)9/(V delta)2 chains of the T cell receptor, lyse Daudi cells but not Raji cells. Here, we have screened four other Burkitt's lymphoma cell lines (HH514, DG75, Ramos, and Wilson), as well as cells derived from a fresh Burkitt's lymphoma, to see if any of them can be recognized by human gamma delta T cells. Leukemia-derived lines MOLT-4, CEM, and K562 have also been included in these studies. Among the Burkitt's lymphomas tested, only Daudi, DG75, and HH514 could be lysed by V(gamma)9/V(delta)2(+) T cell clones derived from the peripheral blood of healthy donors. These T cell clones were also able to lyse the NK sensitive leukemia lines K562 and MOLT-4. When bulk cultures of peripheral blood mononuclear cells from healthy donors were cultured with different Burkitt's lymphoma or leukemia cell lines, only Daudi stimulated the outgrowth of gamma delta T cells. Similarly, only Daudi cells could stimulate proliferation of gamma delta T cell clones, and the response was enhanced significantly in the presence of interleukin-2. These data and our prior observations showing the use of the V(gamma)9/V(delta)2 TCR type by Daudi-reactive human gamma delta T cells indicate that Daudi cells are not representative of other Burkitt's lymphoma cell lines. (C) 1994 Academic Press, Inc.
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页码:54 / 61
页数:8
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