2-SUBSTITUTED 2-AMINOETHANOL - MINIMUM ESSENTIAL STRUCTURE FOR IMMUNOSUPPRESSIVE ACTIVITY OF ISP-I (MYRIOCIN)

被引：25
作者：
FUJITA, T
HIROSE, R
HAMAMICHI, N
KITAO, Y
SASAKI, S
YONETA, M
CHIBA, K
机构：
[1] TAITO CO LTD,RES LAB,NAGATA KU,KOBE,HYOGO 653,JAPAN
[2] KYOTO UNIV,FAC PHARMACEUT SCI,SAKYO KU,KYOTO 60601,JAPAN
[3] YOSHITOMI PHARMACEUT IND LTD,RES LABS,IRUMA,SAITAMA 358,JAPAN
来源：
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1995年 / 5卷 / 16期
关键词：
D O I：
10.1016/0960-894X(95)00304-C
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
2-Substituted 2-aminoethanol was shown to be the minimum essential structure for the immunosuppressive activity of ISP-I (myriocin, thermozymocidin) by simplification of 2-substituted 2-amino-1,3-propanediol, which was generated by modification of ISP-I. Among the series, 2-amino-4-(4-octylphenyl)butanol hydrochloride displayed comparably potent activity to 2-amino-2-[2-(4-octylphenyl)ethyl]-1,3-propanediol hydrochloride, FTY720.
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页码：1857 / 1860
页数：4
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