P53 EXPRESSION IN ANAPLASTIC CARCINOMAS ARISING FROM THYROID PAPILLARY CARCINOMAS

被引：31
|
作者：
MATIASGUIU, X
CUATRECASAS, M
MUSULEN, E
PRAT, J
机构：
[1] Department of Pathology, Hospital de la Santa Creu i Sant Pau, 08025 Barcelona
来源：
JOURNAL OF CLINICAL PATHOLOGY | 1994年 / 47卷 / 04期
关键词：
D O I：
10.1136/jcp.47.4.337
中图分类号：
R36 [病理学];
学科分类号：
100104 ;
摘要：
Aim-To study the expression of p53 tumour suppressor gene in anaplastic carcinomas arising from thyroid papillary carcinomas. Methods-Formalin fixed, paraffin wax embedded tissues from four cases of anaplastic carcinomas associated with thyroid papillary carcinomas were studied by immunohistochemistry with two different p53 monoclonal antibodies. Results-The anaplastic component showed nuclear immunostaining in two cases, but not in the other two. In all cases the papillary carcinoma component was negative. Conclusion-The results support the hypothesis that p53 stimulates tumour progression in thyroid tumours.
引用
收藏
页码：337 / 339
页数：3
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