NERVE GROWTH-FACTOR RECEPTOR EXPRESSION IN THE YOUNG AND ADULT-RAT OLFACTORY SYSTEM

被引：64
作者：
VICKLAND, H
WESTRUM, LE
KOTT, JN
PATTERSON, SL
BOTHWELL, MA
机构：
[1] UNIV WASHINGTON, DEPT PHYSIOL & BIOPHYS, SEATTLE, WA 98195 USA
[2] UNIV WASHINGTON, DEPT BIOL STRUCT, SEATTLE, WA 98195 USA
来源：
BRAIN RESEARCH | 1991年 / 565卷 / 02期
关键词：
NERVE GROWTH FACTOR; OLFACTORY; GLIA; IMMUNOCYTOCHEMISTRY; SENSORY; RAT; 1ST CRANIAL NERVE;
D O I：
10.1016/0006-8993(91)91659-O
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Nerve growth factor (NGF) and its receptor (NGFR) are proteins that have a role in the normal development and survival of neurons in the peripheral and central nervous systems. During development, NGF is necessary for outgrowth of axons and establishment of synapses, and NGFR is the transmembrane protein that binds NGF and brings it into the cell. NGF and NGFR expression in the rat olfactory system have been studied previously, and age differences in NGFR are explored further in this study, using immunocytochemistry and immunoelectron microscopy to determine the changes in two different ages: postnatal day 5 and the adult. Dramatic differences were found in the distribution of NGFR immunoreactivity in the olfactory system of each of the two ages studied. Electron microscopy revealed that glial cells were responsible for this immunoreactivity.
引用
收藏
页码：269 / 279
页数：11
相关论文
共 54 条
[1]   DETECTION OF A NERVE GROWTH-FACTOR RECEPTOR ON FETAL HUMAN SCHWANN-CELLS IN CULTURE - ABSENCE OF THE RECEPTOR ON FETAL HUMAN ASTROCYTES [J].
ASSOULINE, JG ;
PANTAZIS, NJ .
DEVELOPMENTAL BRAIN RESEARCH, 1989, 45 (01) :1-14
[2]   SCHWANN-CELLS OF THE OLFACTORY NERVES CONTAIN GLIAL FIBRILLARY ACIDIC PROTEIN AND RESEMBLE ASTROCYTES [J].
BARBER, PC ;
LINDSAY, RM .
NEUROSCIENCE, 1982, 7 (12) :3077-3090
[3]   MATURATION AND PLASTICITY IN THE OLFACTORY SYSTEM OF VERTEBRATES [J].
BRUNJES, PC ;
FRAZIER, LL .
BRAIN RESEARCH REVIEWS, 1986, 11 (01) :1-45
[4]   DIFFERENTIAL EXPRESSION OF THE NERVE GROWTH-FACTOR RECEPTOR GENE IN MULTIPLE BRAIN-AREAS [J].
BUCK, CR ;
MARTINEZ, HJ ;
CHAO, MV ;
BLACK, IB .
DEVELOPMENTAL BRAIN RESEARCH, 1988, 44 (02) :259-268
[5]   ANALYSIS OF NEUROGENESIS IN A MAMMALIAN NEUROEPITHELIUM - PROLIFERATION AND DIFFERENTIATION OF AN OLFACTORY NEURON PRECURSOR INVITRO [J].
CALOF, AL ;
CHIKARAISHI, DM .
NEURON, 1989, 3 (01) :115-127
[6]  
CHANDLER CE, 1984, J BIOL CHEM, V259, P6882
[7]   LECTINS DEMARCATE THE BARREL SUBFIELD IN THE SOMATOSENSORY CORTEX OF THE EARLY POSTNATAL MOUSE [J].
COOPER, NGF ;
STEINDLER, DA .
JOURNAL OF COMPARATIVE NEUROLOGY, 1986, 249 (02) :157-169
[8]   MONOCLONAL-ANTIBODY TO GLIAL FIBRILLARY ACIDIC PROTEIN REVEALS A PARCELLATION OF INDIVIDUAL BARRELS IN THE EARLY POSTNATAL MOUSE SOMATOSENSORY CORTEX [J].
COOPER, NGF ;
STEINDLER, DA .
BRAIN RESEARCH, 1986, 380 (02) :341-348
[9]  
CUSCHIERI A, 1975, J ANAT, V119, P471
[10]  
DOUCETTE JR, 1983, J ANAT, V137, P1
123456