SUSCEPTIBILITY TO PROTEOLIPID APOPROTEIN AND ITS ENCEPHALITOGENIC DETERMINANTS IN MICE

被引：29

作者：

ENDOH, M

KUNISHITA, T

NIHEI, J

NISHIZAWA, M

TABIRA, T

机构：

[1] Division of Demyelinating, Disease and Aging, National Inst. Neuroscience, Tokyo 187

来源：

INTERNATIONAL ARCHIVES OF ALLERGY AND APPLIED IMMUNOLOGY | 1990年 / 92卷 / 04期

关键词：

D O I：

10.1159/000235176

中图分类号：

R392 [医学免疫学];

学科分类号：

100102 ;

摘要：

We investigated in mice strain differences in induction of experimental allergic encephalomyelitis by proteolipid apoprotein and studied encephalitogenic determinants. SJL/J, C3H/He, CBA/J and A/J mice were high responders, BALB/c and AKR/J mice were moderately susceptible, and DBA/2, B6 and congenic strains of B10 background were low responders. Synthetic peptide 136-150 was encephalitogenic for SJL/J mice, and 215-232 was encephalitogenic for C3H/He mice. These encephalitogenic determinants are present in the extracellular portion of proteolipid apoprotein in myelin.

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页码：433 / 438

页数：6

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