Acute renal failure, systemic lupus erythematosus and thrombotic microangiopathy following treatment with beta-interferon for multiple sclerosis: case report and review of the literature

被引：11

作者：

Hansen, Thomas ^{[1
]}

New, David ^{[1
]}

Reeve, Roy ^{[2
]}

Donne, Rosemary ^{[1
]}

Stephens, William ^{[3
]}

机构：

[1] Salford Royal NHS Fdn Trust, Renal Unit, Salford, Greater Manches, England

[2] Salford Royal NHS Fdn Trust, Dept Pathol, Salford, Greater Manches, England

[3] Trafford Healthcare NHS Trust, Dept Internal Med, Sale, England

来源：

CLINICAL KIDNEY JOURNAL | 2009年 / 2卷 / 06期

关键词：

acute renal failure; anti-phospholipid syndrome; beta-interferon; multiple sclerosis; systemic lupus erythematosus;

D O I：

10.1093/ndtplus/sfp113

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

We report a man with type 1 diabetes mellitus, autoimmune hypothyroidism and a tentative diagnosis of multiple sclerosis. Following treatment with beta interferon, he developed systemic lupus erythematosus with pericarditis, pleural effusions, cerebral infarction associated with anti-phospholipid antibody and acute renal failure due to thrombotic microangiopathy. He responded well to immunosuppression and anticoagulation. These complications may represent the most severe autoimmune reaction to beta interferon reported to date.

引用

页码：466 / 468

页数：3

共 5 条

[1] Syndromes and complications of interferon therapy [J].

Borg, Frances A. Y. ;

Isenberg, David A. .

CURRENT OPINION IN RHEUMATOLOGY, 2007, 19 (01) :61-66

[2] Systemic lupus erythematosus induced by therapy with interferon-β in a patient with multiple sclerosis [J].

Crispín, JC ;

Díaz-Jouanen, E .

LUPUS, 2005, 14 (06) :495-496

[3] Multiple sclerosis, neuropsychiatric lupus and antiphospholipid syndrome: where do we stand? [J].

Ferreira, S ;

D'Cruz, DP ;

Hughes, GRV .

RHEUMATOLOGY, 2005, 44 (04) :434-442

[4]

Herrera WG, 1999, NEUROLOGY, V52, pA135

[5] Hemolytic uremic syndrome associated with β-interferon therapy for chronic hepatitis C [J].

Ubara, Y ;

Hara, S ;

Takedatu, H ;

Katori, H ;

Yamada, K ;

Yoshihara, K ;

Matsushita, Y ;

Yokoyama, K ;

Takemoto, F ;

Yamada, A ;

Takagawa, R ;

Endo, Y ;

Hara, M ;

Koida, I ;

Kumada, H .

NEPHRON, 1998, 80 (01) :107-108

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