IDENTIFICATION OF A MEMBER OF THE MAPKKK FAMILY AS A POTENTIAL MEDIATOR OF TGF-BETA SIGNAL-TRANSDUCTION

被引：1193
作者：
YAMAGUCHI, K
SHIRAKABE, T
SHIBUYA, H
IRIE, K
OISHI, I
UENO, N
TANIGUCHI, T
NISHIDA, E
MATSUMOTO, K
机构：
[1] HOKKAIDO UNIV, FAC PHARMACEUT SCI, SAPPORO, HOKKAIDO 060, JAPAN
[2] NAGOYA UNIV, FAC SCI, DEPT MOLEC BIOL, CHIKUSA KU, NAGOYA, AICHI 46401, JAPAN
[3] KYOTO UNIV, INST VIRUS RES, DEPT GENET & MOLEC BIOL, SAKYO KU, KYOTO 60601, JAPAN
[4] OSAKA UNIV, INST MOLEC & CELLULAR BIOL, SUITA, OSAKA 565, JAPAN
来源：
SCIENCE | 1995年 / 270卷 / 5244期
关键词：
D O I：
10.1126/science.270.5244.2008
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
The mitogen-activated protein kinase (MAPK) pathway is a conserved beta eukaryotic signaling module that converts receptor signals into various outputs. MAPK is activated through phosphorylation by MAPK kinase (MAPKK), which is first activated by MAPKK kinase (MAPKKK). A genetic selection based on a MAPK pathway in yeast was used to identify a mouse protein kinase (TAK1) distinct from other members of the MAPKKK family. TAK1 was shown to participate in regulation of transcription by transforming growth factor-beta (TGF-beta). Furthermore, kinase activity of TAK1 was stimulated in response to TGF-beta and bone morphogenetic protein. These results suggest that TAK1 functions as a mediator in the signaling pathway of TGF-beta superfamily members.
引用
收藏
页码：2008 / 2011
页数：4
相关论文
共 28 条
[1]   AN ASSAY FOR TRANSFORMING GROWTH-FACTOR-BETA USING CELLS TRANSFECTED WITH A PLASMINOGEN-ACTIVATOR INHIBITOR-1 PROMOTER LUCIFERASE CONSTRUCT [J].
ABE, M ;
HARPEL, JG ;
METZ, CN ;
NUNES, I ;
LOSKUTOFF, DJ ;
RIFKIN, DB .
ANALYTICAL BIOCHEMISTRY, 1994, 216 (02) :276-284
[2]   DIVERSITY IN FUNCTION AND REGULATION OF MAP KINASE PATHWAYS [J].
BLUMER, KJ ;
JOHNSON, GL .
TRENDS IN BIOCHEMICAL SCIENCES, 1994, 19 (06) :236-240
[3]   MAMMALIAN MITOGEN-ACTIVATED PROTEIN-KINASE KINASE KINASE (MEKK) CAN FUNCTION IN A YEAST MITOGEN-ACTIVATED PROTEIN-KINASE PATHWAY DOWNSTREAM OF PROTEIN-KINASE-C [J].
BLUMER, KJ ;
JOHNSON, GL ;
LANGECARTER, CA .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1994, 91 (11) :4925-4929
[4]   THE COMPLETE CODING SEQUENCE OF THE HUMAN RAF ONCOGENE AND THE CORRESPONDING STRUCTURE OF THE C-RAF-1 GENE [J].
BONNER, TI ;
OPPERMANN, H ;
SEEBURG, P ;
KERBY, SB ;
GUNNELL, MA ;
YOUNG, AC ;
RAPP, UR .
NUCLEIC ACIDS RESEARCH, 1986, 14 (02) :1009-1015
[5]   MAPKS - NEW JNK EXPANDS THE GROUP [J].
DAVIS, RJ .
TRENDS IN BIOCHEMICAL SCIENCES, 1994, 19 (11) :470-473
[6]   THE PROTEIN-KINASE FAMILY - CONSERVED FEATURES AND DEDUCED PHYLOGENY OF THE CATALYTIC DOMAINS [J].
HANKS, SK ;
QUINN, AM ;
HUNTER, T .
SCIENCE, 1988, 241 (4861) :42-52
[7]   MAP KINASE PATHWAYS IN YEAST - FOR MATING AND MORE [J].
HERSKOWITZ, I .
CELL, 1995, 80 (02) :187-197
[8]  
HIRAI R, COMMUNICATION
[9]   STIMULATORY EFFECTS OF YEAST AND MAMMALIAN 14-3-3-PROTEINS ON THE RAF PROTEIN-KINASE [J].
IRIE, K ;
GOTOH, Y ;
YASHAR, BM ;
ERREDE, B ;
NISHIDA, E ;
MATSUMOTO, K .
SCIENCE, 1994, 265 (5179) :1716-1719
[10]  
IRIE K, UNPUB
123