ANTIDIABETIC AGENTS - A NEW CLASS OF REVERSIBLE CARNITINE PALMITOYLTRANSFERASE-I INHIBITORS

被引：39

作者：

ANDERSON, RC ^{[1
]}

BALESTRA, M ^{[1
]}

BELL, PA ^{[1
]}

DEEMS, RO ^{[1
]}

FILLERS, WS ^{[1
]}

FOLEY, JE ^{[1
]}

FRASER, JD ^{[1
]}

MANN, WR ^{[1
]}

RUDIN, M ^{[1
]}

VILLHAUER, EB ^{[1
]}

机构：

[1] SANTEN PHARMACEUT CO LTD,PRECLIN RES,DEPT DISCOVERY & TECHNOL,CH-4002 BASEL,SWITZERLAND

来源：

JOURNAL OF MEDICINAL CHEMISTRY | 1995年 / 38卷 / 18期

关键词：

D O I：

10.1021/jm00018a003

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

[No abstract available]

引用

页码：3448 / 3450

页数：3

共 27 条

[1]

BELL PR, IN PRESS

[2] INVITRO REVERSAL OF THE FASTING STATE OF LIVER-METABOLISM IN THE RAT - RE-EVALUATION OF THE ROLES OF INSULIN AND GLUCOSE [J].

BOYD, ME ;

ALBRIGHT, EB ;

FOSTER, DW ;

MCGARRY, JD .

JOURNAL OF CLINICAL INVESTIGATION, 1981, 68 (01) :142-152

[3] CHRONIC INHIBITION OF FATTY-ACID OXIDATION - NEW MODEL OF DIASTOLIC DYSFUNCTION [J].

BRESSLER, R ;

GAY, R ;

COPELAND, JG ;

BAHL, JJ ;

BEDOTTO, J ;

GOLDMAN, S .

LIFE SCIENCES, 1989, 44 (25) :1897-1906

[4] SOME KINETIC STUDIES ON MECHANISM OF ACTION OF CARNITINE ACETYLTRANSFERASE [J].

CHASE, JFA ;

TUBBS, PK .

BIOCHEMICAL JOURNAL, 1966, 99 (01) :32-&

[5]

COWARD JK, 1979, DEV BIOCHEM, V6, P13

[6]

DECLERCQ PE, 1987, J BIOL CHEM, V262, P9812

[7] THE TRIUMVIRATE - BETA-CELL, MUSCLE, LIVER - A COLLUSION RESPONSIBLE FOR NIDDM [J].

DEFRONZO, RA .

DIABETES, 1988, 37 (06) :667-687

[8] HEMIPALMITOYLCARNITINIUM, A STRONG COMPETITIVE INHIBITOR OF PURIFIED HEPATIC CARNITINE PALMITOYLTRANSFERASE [J].

GANDOUR, RD ;

COLUCCI, WJ ;

STELLY, TC ;

BRADY, PS ;

BRADY, LJ .

ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, 1988, 267 (02) :515-520

[9] (+)-HEMIPALMITOYLCARNITINIUM STRONGLY INHIBITS CARNITINE PALMITOYLTRANSFERASE-I IN INTACT MITOCHONDRIA [J].

GANDOUR, RD ;

LEUNG, OT ;

GREWAY, AT ;

RAMSAY, RR ;

NICABHAIRD, N ;

FRONCZEK, FR ;

BELLARD, BM ;

KUMARAVEL, G .

JOURNAL OF MEDICINAL CHEMISTRY, 1993, 36 (02) :237-242

[10] RELATIONSHIPS BETWEEN PLASMA-FREE FATTY-ACID CONCENTRATION, ENDOGENOUS GLUCOSE-PRODUCTION, AND FASTING HYPERGLYCEMIA IN NORMAL AND NON-INSULIN-DEPENDENT DIABETIC INDIVIDUALS [J].

GOLAY, A ;

SWISLOCKI, ALM ;

CHEN, YDI ;

REAVEN, GM .

METABOLISM-CLINICAL AND EXPERIMENTAL, 1987, 36 (07) :692-696

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