MONOAMINE ANTAGONISM WITH RESPECT TO A DIRECT EFFECT OF NEUROLEPTICS ON RELEASE OF EXCITATING AMINO-ACID NEUROMEDIATORS

被引：0

作者：

KOVALYOV, GI ^{[1
]}

PRIKHOZHAN, AV ^{[1
]}

RAYEVSKY, KS ^{[1
]}

机构：

[1] ACAD MED SCI USSR,PHARMACOL RES INST,NEUROCHEM PHARMACOL LAB,MOSCOW 125315,USSR

来源：

FARMAKOLOGIYA I TOKSIKOLOGIYA | 1990年 / 53卷 / 05期

关键词：

D O I：

暂无

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

In the experiments on the superfused synaptosomes of the rat brain cortex it was shown that both typical and atypical neuroleptics in the micromolar range of concentrations decrease K+-stimulated H-3-D-aspartate release. Serotonin (10(-5) M) and dopamine (10(-7) M) do not affect D-aspartate release Serotonin abolishes the action of all typical neuroleptics studied (haloperidol, chlorpromasine, fluphenasine) and of sulpiride and clozapine, but not of carbidine. Dopamine antagonizes only the effect of atypical neuroleptics.

引用

页码：22 / 24

页数：3

共 13 条

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