THE ORGANIZATION AND CONSERVATION OF THE HUMAN SURFEIT GENE-CLUSTER AND ITS LOCALIZATION TELOMERIC TO THE C-ABL AND CAN PROTOONCOGENES AT CHROMOSOME BAND 9Q34.1

被引：29
作者：
YON, J
JONES, T
GARSON, K
SHEER, D
FRIED, M
机构：
[1] IMPERIAL CANC RES FUND, EUKARYOT GENE ORGAN LAB, POB 123, LINCOLNS INN FIELDS, LONDON WC2A 3PX, ENGLAND
[2] IMPERIAL CANC RES FUND, HUMAN CYTOGEN LAB, LONDON WC2A 3PX, ENGLAND
来源：
HUMAN MOLECULAR GENETICS | 1993年 / 2卷 / 03期
关键词：
D O I：
10.1093/hmg/2.3.237
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The mouse Surfeit locus contains an unusually tight cluster of six housekeeping genes (Surf-1 to -6) which are unrelated by sequence homology. Using a mouse Surfeit locus probe, a 16 kb clone has been isolated which contains the human Surf-1 and Surf-3 genes and regions of the human Surf-2 and Surf-5 genes. The organization and juxtaposition of these human Surfeit locus genes are the same as found in the mouse. Using the human clone as a biotinylated probe for fluorescence in situ hybridization (FISH) we have confirmed the location of the human Surfeit locus to chromosome band 9q34. Metaphase spreads of human chronic myeloid leukemic cells containing the t(9;22)(q34;q11) translocation involving the c-abl gene at 9q34.1 and acute nonlymphocytic leukemic cells containing the t(6;9)(q34;p23) tranlocation involving the can gene at 9q34.1 were analyzed by FISH using the human Surfeit clone as a probe. These analyses locate the human Surfeit locus telomeric to the c-abl and can genes at chromosome band 9q34.1.
引用
收藏
页码：237 / 240
页数：4
相关论文
共 26 条
  • [1] THE ORGANIZATION AND EXPRESSION OF THE HUMAN L7A RIBOSOMAL-PROTEIN GENE
    COLOMBO, P
    YON, J
    FRIED, M
    [J]. BIOCHIMICA ET BIOPHYSICA ACTA, 1991, 1129 (01) : 93 - 95
  • [2] CONSERVATION OF THE ORGANIZATION OF 5 TIGHTLY CLUSTERED GENES OVER 600 MILLION YEARS OF DIVERGENT EVOLUTION
    COLOMBO, P
    YON, J
    GARSON, K
    FRIED, M
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1992, 89 (14) : 6358 - 6362
  • [3] A STRATEGY TO DETECT AND ISOLATE AN INTRON-CONTAINING GENE IN THE PRESENCE OF MULTIPLE PROCESSED PSEUDOGENES
    DAVIES, B
    FEO, S
    HEARD, E
    FRIED, M
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1989, 86 (17) : 6691 - 6695
  • [4] LARGE INVERTED DUPLICATIONS ARE ASSOCIATED WITH GENE AMPLIFICATION
    FORD, M
    FRIED, M
    [J]. CELL, 1986, 45 (03) : 425 - 430
  • [5] GARSON K, UNPUB
  • [6] RIBOSOMAL-PROTEIN L7A IS ENCODED BY A GENE (SURF-3) WITHIN THE TIGHTLY CLUSTERED MOUSE SURFEIT LOCUS
    GIALLONGO, A
    YON, J
    FRIED, M
    [J]. MOLECULAR AND CELLULAR BIOLOGY, 1989, 9 (01) : 224 - 231
  • [7] GENE AMPLIFICATION ACCOMPANIED BY THE LOSS OF A CHROMOSOME CONTAINING THE NATIVE ALLELE AND THE APPEARANCE OF THE AMPLIFIED DNA AT A NEW CHROMOSOMAL LOCATION
    HEARD, E
    WILLIAMS, SV
    SHEER, D
    FRIED, M
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1991, 88 (18) : 8242 - 8246
  • [8] UNIQUE FUSION OF BCR AND C-ABL GENES IN PHILADELPHIA-CHROMOSOME POSITIVE ACUTE LYMPHOBLASTIC-LEUKEMIA
    HERMANS, A
    HEISTERKAMP, N
    VONLINDERN, M
    VANBAAL, S
    MEIJER, D
    VANDERPLAS, D
    WIEDEMANN, LM
    GROFFEN, J
    BOOTSMA, D
    GROSVELD, G
    [J]. CELL, 1987, 51 (01) : 33 - 40
  • [9] ONE OF THE TIGHTLY CLUSTERED GENES OF THE MOUSE SURFEIT LOCUS IS A HIGHLY EXPRESSED MEMBER OF A MULTIGENE FAMILY WHOSE OTHER MEMBERS ARE PREDOMINANTLY PROCESSED PSEUDOGENES
    HUXLEY, C
    WILLIAMS, T
    FRIED, M
    [J]. MOLECULAR AND CELLULAR BIOLOGY, 1988, 8 (09) : 3898 - 3905
  • [10] THE MOUSE SURFEIT LOCUS CONTAINS A CLUSTER OF 6 GENES ASSOCIATED WITH 4 CPG-RICH ISLANDS IN 32 KILOBASES OF GENOMIC DNA
    HUXLEY, C
    FRIED, M
    [J]. MOLECULAR AND CELLULAR BIOLOGY, 1990, 10 (02) : 605 - 614
123