THE EFFECT OF PENTACHLOROPHENOL AND ITS METABOLITE TETRACHLOROHYDROQUINONE ON CELL-GROWTH AND THE INDUCTION OF DNA DAMAGE IN CHINESE HAMSTER OVARY CELLS

被引：40

作者：

EHRLICH, W ^{[1
]}

机构：

[1] FREE UNIV BERLIN,FACHBEREICH BIOL,INST BIOCHEM & MOLEK BIOL,W-1000 BERLIN 33,GERMANY

来源：

MUTATION RESEARCH | 1990年 / 244卷 / 04期

关键词：

Cell growth; CHO cells; DNA damage; Pentachlorophenol; Tetrachlorohydroquinone;

D O I：

10.1016/0165-7992(90)90076-V

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

It is shown that p-tetrachlorohydroquinone (TCH), the metabolite of the environmental chemical pentachlorophenol (PCP), is more toxic to cultured CHO cells than PCP, and that it causes DNA single-strand breaks and/or alkali-labile sites at concentrations of 2-10 μg/ml as demonstrated by the alkaline elution technique. © 1990.

引用

页码：299 / 302

页数：4

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