THE AMPA ANTAGONIST NBQX PROVIDES PARTIAL PROTECTION OF RAT CEREBELLAR PURKINJE-CELLS AFTER CARDIAC-ARREST AND RESUSCITATION

被引：29

作者：

BRASKO, J

RAI, P

SABOL, MK

PATRIKIOS, P

ROSS, DT

机构：

[1] UNIV PENN,DIV NEUROSURG,CTR HEAD INJURT,PHILADELPHIA,PA 19104

[2] THOMAS JEFFERSON UNIV,JEFFERSON MED COLL,DEPT PATHOL ANAT & CELL BIOL,PHILADELPHIA,PA 19107

[3] UNIV ROCHESTER,DEPT ANAT & NEUROBIOL,ROCHESTER,NY 14642

[4] MED COLL PENN,PHILADELPHIA,PA 19125

[5] HAHNEMANN UNIV,ANIM RESOURCES LAB,PHILADELPHIA,PA 19125

来源：

BRAIN RESEARCH | 1995年 / 699卷 / 01期

关键词：

CARDIAC ARREST; ISCHEMIA; CEREBELLAR DEGENERATION; NEUROPROTECTION; AMPA ANTAGONIST;

D O I：

10.1016/0006-8993(95)01015-N

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Purkinje cell loss in adult rats resuscitated following cardiac arrest is analogous to that seen following human cardiac arrest. Administration of the competitive AMPA antagonist NBQX to rats resuscitated after 10 min duration cardiac arrest rescued 21.5% of the vulnerable Purkinje cell population. These results support the hypothesis that sustained postischemic overexcitation of AMPA receptors may be a driving force in the process of Purkinje cell degeneration.

引用

页码：133 / 138

页数：6

共 36 条

[1] RESPONSES TO EXCITATORY AMINO-ACIDS OF PURKINJE-CELLS AND NEURONS OF THE DEEP NUCLEI IN CEREBELLAR SLICE CULTURES [J].