RADIOPROTECTIVE EFFECT OF STOBADINE IN THE MOUSE MICRONUCLEUS TEST

被引：9
作者：
CHORVATOVICOVA, D
机构：
[1] Institute of Experimental Pharmacology, Slovak Academy of Sciences, 842 16 Bratislava
来源：
MUTATION RESEARCH | 1994年 / 324卷 / 1-2期
关键词：
STOBADINE DIPALMITATE; (MICE) MICRONUCLEUS TEST; PERIPHERAL BLOOD RETICULOCYTES; CO-60; IRRADIATION; FREE RADICALS; ANTIMUTAGENIC EFFECTS; RADIOPROTECTION;
D O I：
10.1016/0165-7992(94)90060-4
中图分类号：
Q3 [遗传学];
学科分类号：
071007 ; 090102 ;
摘要：
Induction of micronuclei was studied 40 h post irradiation in peripheral blood reticulocytes of male mice treated or not with stobadine dipalmitate (70.07 mg/kg body weight) at two time intervals (2 h or 1 h) prior to and immediately after 6.5 Gy Co-60 exposure. A significant decrease of micronucleated reticulocytes was observed in the group of mice pretreated 2 h (P < 0.05) or 1 h (P < 0.01) before irradiation. Co-60 irradiation followed by treatment with stobadine did not lead to the same protective effect in the micronucleus assay. It is therefore assumed that a radical-scavenging mechanism must be involved in radioprotection by stobadine.
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页码：7 / 11
页数：5
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