SEASONAL-VARIATION IN SERUM 25-HYDROXY VITAMIN-D-3 DOES NOT AFFECT 1,25-DIHYDROXY VITAMIN-D

被引：33

作者：

HINE, TJ ^{[1
]}

ROBERTS, NB ^{[1
]}

机构：

[1] UNIV LIVERPOOL,ROYAL LIVERPOOL HOSP,DEPT CLIN CHEM,LIVERPOOL L7 8XP,ENGLAND

来源：

ANNALS OF CLINICAL BIOCHEMISTRY | 1994年 / 31卷

关键词：

SCROLLING 3-MONTH ANALYSIS; SUNLIGHT ASSESSMENT;

D O I：

10.1177/000456329403100105

中图分类号：

R446 [实验室诊断]; R-33 [实验医学、医学实验];

学科分类号：

1001 ;

摘要：

The seasonal variation of serum 25-hydroxy vitamin D-3 and 1,25-dihydroxy-vitamin D has been investigated. Blood was taken from 27 healthy volunteers, aged 21-44 years old at 3 monthly intervals over a period of 1 year. A scrolling monthly programme with 12 quarterly (3 month) time periods was developed. A summer associated increase in 25-hydroxy vitamin D-3 was significantly correlated with but lagged behind by 2 months, the increase in recorded sunlight hours. However, four individuals showed no seasonal rise but maintained constant concentrations throughout the year within the established reference range. Serum 1,25-dihydroxy vitamin D showed marked intra-individual variability with no seasonal pattern although the highest concentration (180 pmol/L) was observed in the winter and no concentration greater than 108 pmol/L in the summer.

引用

页码：31 / 34

页数：4