CHARACTERIZATION OF CARBOHYDRATES IN THE ALPHA-2-MACROGLOBULIN RECEPTOR

被引：10

作者：

JENSEN, PH ^{[1
]}

GLIEMANN, J ^{[1
]}

ORNTOFT, T ^{[1
]}

机构：

[1] AARHUS UNIV HOSP,DEPT CLIN CHEM,DK-8000 AARHUS,DENMARK

来源：

FEBS LETTERS | 1992年 / 305卷 / 02期

关键词：

ALPHA-2-MACROGLOBULIN RECEPTOR; LOW DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN; GLYCOSYLATION; LECTIN;

D O I：

10.1016/0014-5793(92)80879-L

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Carbohydrates were characterized in the human placental alpha-2-macroglobulin receptor and its associated protein. Carbohydrates, largely N-linked, contributed to about 18% of the size of the receptor alpha-chain and to about 25% of the beta-chain. The 40 kDa receptor-associated protein also contained carbohydrate. The alpha- and beta-chains contained a wide variety of carbohydrates as judged by binding of lectins. Monosaccharide-competing inhibition of alpha-2M-methylamine binding by WGA suggested a functional significance of sugars in binding of ligands to the alpha-chain.

引用

页码：129 / 132

页数：4

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