PROTECTIVE ROLE OF ASCORBIC-ACID AGAINST ASBESTOS INDUCED TOXICITY IN RAT LUNG - INVITRO STUDY

被引：12
作者：
KHAN, SG
ALI, S
RAHMAN, Q
机构：
[1] Industrial Toxicology Research Centre, Lucknow, UP, P.Box-80, M.G. Marg
来源：
DRUG AND CHEMICAL TOXICOLOGY | 1990年 / 13卷 / 2-3期
关键词：
D O I：
10.3109/01480549009018125
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Asbestos fibers adsorb cytochrome P-450 and P-448 proteins from rat lung micosomal fractions and liberate heme from cytochrome P-448 on prolonged incubation in vitro. further, fibers, decrease the activities of benzo(a)pyrene hydroxylase and glutathione-S-transferase in microsomal and cytosolic fractions respectively. Mineral fibers also stimulate both the enzymatic (NADPH-induced) and non-enzymatic (Fe2+ -induced) lipid peroxidation in microsomal fractions. Preincubation of microsomal and cytosolic fractions with a physiological concentration of ascorbic acid ameliorates, to a large extent, the changes induced by asbestos fibers. © 1990 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted.
引用
收藏
页码：249 / 256
页数：8
相关论文
共 28 条
  • [1] MODIFIED METHOD FOR ASSAY OF BENZO[A]PYRENE HYDROXYLASE
    DEHNEN, W
    TOMINGAS, R
    ROOS, J
    [J]. ANALYTICAL BIOCHEMISTRY, 1973, 53 (02) : 373 - 383
  • [2] EFFECTS OF INTAKE OF L-ASCORBIC-ACID ON THE INCIDENCE OF DERMAL NEOPLASMS INDUCED IN MICE BY ULTRAVIOLET-LIGHT
    DUNHAM, WB
    ZUCKERKANDL, E
    REYNOLDS, R
    WILLOUGHBY, R
    MARCUSON, R
    BARTH, R
    PAULING, L
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES, 1982, 79 (23): : 7532 - 7536
  • [3] FALK JE, 1974, PORPHYRINS METALLOPO, P182
  • [4] FISHER RA, 1954, STATISTICAL METHODS
  • [5] THE STIMULATORY EFFECTS OF ASBESTOS ON NADPH-DEPENDENT LIPID-PEROXIDATION IN RAT-LIVER MICROSOMES
    FONTECAVE, M
    MANSUY, D
    JAOUEN, M
    PEZERAT, H
    [J]. BIOCHEMICAL JOURNAL, 1987, 241 (02) : 561 - 565
  • [6] ASBESTOS CATALYZES THE FORMATION OF THE 6-OXOBENZO[A]PYRENE RADICAL FROM 6-HYDROXYBENZO[A]PYRENE
    GRACEFFA, P
    WEITZMAN, SA
    [J]. ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, 1987, 257 (02) : 481 - 484
  • [7] CROCIDOLITE-INDUCED LIPID-PEROXIDATION .2. ROLE OF ANTIOXIDANTS
    GULUMIAN, M
    KILROESMITH, TA
    [J]. ENVIRONMENTAL RESEARCH, 1987, 44 (02) : 254 - 259
  • [8] HABIG WH, 1974, J BIOL CHEM, V249, P7130
  • [9] ASCORBIC-ACID INHIBITS THE SQUAMOUS METAPLASIA THAT RESULTS FROM TREATMENT OF TRACHEAL EXPLANTS WITH ASBESTOS OR BENZO[A]PYRENE-COATED ASBESTOS
    HOLTZ, G
    BRESNICK, E
    [J]. CANCER LETTERS, 1988, 42 (1-2) : 23 - 28
  • [10] HUNTER FE, 1963, J BIOL CHEM, V238, P828
123