Overexpression of MDA-7/IL-24 as an anticancer cytokine in gene therapy of thyroid carcinoma

被引：17
|
作者：
Mirzaei, Mehri Hajikhan [1 ]
Esmaeilzadeh, Abdolreza [2 ,3 ]
机构：
[1] Univ Tokyo, Grad Sch Frontier Sci, Dept Med Genom, Tokyo, Japan
[2] Zanjan Univ Med Sci, Fac Med, Dept Immunol, Zanjan, Iran
[3] Zanjan Univ Med Sci, Fac Med, Canc Gene Therapy Res Ctr, Zanjan, Iran
来源：
JOURNAL OF MEDICAL HYPOTHESES AND IDEAS | 2014年 / 8卷 / 01期
关键词：
Thyroid carcinoma; MDA-7/IL-24; Xenograft mouse model; HTori cell; Immune gene therapy;
D O I：
10.1016/j.jmhi.2013.06.002
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
The annual incidence of thyroid cancer worldwide is alarming. Despite current various treatments such as surgical resection, radioiodine therapy and chemotherapy/radiotherapy, thyroid carcinoma remains a lethal cancer. Assuredly, the operative and new treatment strategies are necessary to control this malignancy. Gene therapy is regarded as one of the most reliable novel therapeutic methods for hopeless cases of thyroid cancer and those who do not respond to the prevalent treatments. Accumulated evidence suggests that interleukin-24 (IL-24), also known as melanoma differentiation-associated gene-7, has very important roles in regulation of cell differentiation, cell growth and apoptosis, and it is also a promising anticancer agent. Here, we propose that it could be advantageous to evaluate the anti-tumoural effect of IL-24 in a mouse xenograft model of thyroid cancer. (C) 2013 Tehran University of Medical Sciences. Published by Elsevier Ltd.
引用
收藏
页码：7 / 13
页数：7
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