Single-Walled-Carbon-Nanotube-Modified Pyrolytic Graphite Electrode Used as a Simple Sensor for the Determination of Salbutamol in Urine

被引：13

作者：

Goyal, Rajendra N. ^{[1
]}

Bishnoi, Sunita ^{[1
]}

Agrawal, Bharati ^{[1
]}

机构：

[1] Indian Inst Technol Roorkee, Dept Chem, Roorkee 247667, Uttar Pradesh, India

来源：

INTERNATIONAL JOURNAL OF ELECTROCHEMISTRY | 2011年 / 2011卷

关键词：

D O I：

10.4061/2011/373498

中图分类号：

O646 [电化学、电解、磁化学];

学科分类号：

081704 ;

摘要：

A fast and sensitive voltammetric method has been proposed for the determination of salbutamol at single-walled-carbonnanotube-modified edge-plane pyrolytic graphite electrode (SWNT/EPPGE) in human urine. The electrochemical response of salbutamol was determined by square wave voltammetry (SWV) in phosphate buffer solution (PBS) at physiological pH 7.2. The modified electrode showed improved voltammetric response towards the oxidation of salbutamol, and a well-defined anodic peak was observed at similar to 600mV with enhanced peak current in comparison to the bare electrode. Linear calibration plot using SWNT/EPPGE was obtained in the concentration range of 50 to 2500 ngml(-1) with sensitivity and detection limit of 2.15 nA/ngml(-1) and 4.31 ngml(-1), respectively. The developed method has been successfully applied for the determination of salbutamol in commercial preparations and human body fluids. Fast analysis of salbutamol in human urine makes the proposed method of great interest for doping control purposes at the site of competitive games.

引用

页数：8

共 45 条

[1] Osteryoung square wave stripping voltammetry at mercury film electrode for monitoring ultra trace levels of Tarabine PFS and its interaction with ssDNA [J].

Abd El-Hady, D ;

Abdel-Hamid, MI ;

Seliem, MM ;

Andrisano, V ;

El-Maali, NA .

JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, 2004, 34 (05) :879-890

[2] Development of a carbon nanotube paste electrode osmium polymer-mediated biosensor for determination of glucose in alcoholic beverages [J].

Antiochia, Riccarda ;

Gorton, Lo .

BIOSENSORS & BIOELECTRONICS, 2007, 22 (11) :2611-2617

[3] Efficacy and safety of budesonide/formoterol compared with salbutamol in the treatment of acute asthma [J].

Balanag, VM ;

Yunus, F ;

Yang, PC ;

Jorup, C .

PULMONARY PHARMACOLOGY & THERAPEUTICS, 2006, 19 (02) :139-147

[4] Investigation of modified basal plane pyrolytic graphite electrodes: definitive evidence for the electrocatalytic properties of the ends of carbon nanotubes [J].

Banks, CE ;

Moore, RR ;

Davies, TJ ;

Compton, RG .

CHEMICAL COMMUNICATIONS, 2004, (16) :1804-1805

[5] Muscle and serum changes with salbutamol administration in aerobically exercised rats [J].

Cepero, M ;

Pérez-Pertejo, Y ;

Cubría, JC ;

Reguera, R ;

Balaña-Fouce, R ;

Ordóñez, C ;

Escudero, DO .

COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-PHARMACOLOGY TOXICOLOGY & ENDOCRINOLOGY, 2000, 126 (01) :45-51

[6] Separation and determination of abused drugs clenbuterol and salbutamol from complex extractants in swine feed by capillary zone electrophoresis with simple pretreatment [J].

Chen, Qian ;

Fan, Liu-Yin ;

Zhang, Wei ;

Cao, Cheng-Xi .

TALANTA, 2008, 76 (02) :282-287

[7]

Christian G. D., 1962, J ELECTROANAL CHEM, V3, P363

[8] The degradation of salbutamol in ethanolic solutions [J].

Cope, Mike ;

Bautista-Parra, Fernando .

JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, 2010, 52 (02) :210-215

[9] Smart (Nano) materials:: TiO2 nanostructured films to modify electrodes for assembling of new electrochemical probes [J].

Curulli, A ;

Valentini, E ;

Padeletti, G ;

Viticoli, A ;

Caschera, D ;

Palleschi, G .

SENSORS AND ACTUATORS B-CHEMICAL, 2005, 111 :441-449

[10] Determination of dipyridamole in pharmaceutical preparations using square wave voltammetry [J].

de Toledo, RA ;

Castilho, M ;

Mazo, LH .

JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, 2005, 36 (05) :1113-1117

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