Association of MSH6 mutation with glioma susceptibility, drug resistance and progression

被引：26

作者：

Xie, Chaoran ^{[1
,2
]}

Sheng, Hansong ^{[2
]}

Zhang, Nu ^{[2
]}

Li, Shiting ^{[1
]}

Wei, Xiangyu ^{[1
]}

Zheng, Xuesheng ^{[1
]}

机构：

[1] Shanghai Jiao Tong Univ, Dept Neurosurg, Xinhua Hosp, Sch Med, 1665 Kongjiang Rd, Shanghai 200092, Peoples R China

[2] Wenzhou Med Univ, Dept Neurosurg, Affiliated Hosp 2, Wenzhou 325027, Zhejiang, Peoples R China

来源：

MOLECULAR AND CLINICAL ONCOLOGY | 2016年 / 5卷 / 02期

关键词：

mutS homolog 6; mutation; glioma; drug resistance; temozolomide;

D O I：

10.3892/mco.2016.907

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

MutS homolog 6 (MSH6) is one of the mismatch repair proteins and is encoded by the MSH6 gene, which is located on chromosome 2 and is 23,806 bp in length, including 10 exons and 83 untranslated regions. The MSH6 protein consists of 1,358 amino acid residues and forms a heterodimer with another mismatch repair protein, MSH2. The MSH2-MSH6 heterodimeric complex is able to recognize base-base substitution and single-base insertion/deletion mismatches. Germline mutations of MSH6 lead to high susceptibility to glioma, as well as a number of benign or malignant tumors in other organs. However, somatic MSH6 mutations are not associated with susceptibility to glioma. Somatic MSH6 mutations usually follow temozolomide treatment and result in resistance to temozolomide. Subsequently, MSH6 mutations cause a hypermutation in the glioma cell genome, which may accelerate tumor progression.

引用

页码：236 / 240

页数：5

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