CIMETIDINE DOES NOT ALTER SPARFLOXACIN PHARMACOKINETICS

被引：0

作者：

GRIES, JM

HONORATO, J

TABURET, AM

ALVAREZ, MP

SADABA, B

AZANZA, JR

SINGLAS, E

机构：

[1] UNIV NAVARRA,E-31080 PAMPLONA,SPAIN

[2] HOP NECKER ENFANTS MALAD,F-75015 PARIS,FRANCE

来源：

INTERNATIONAL JOURNAL OF CLINICAL PHARMACOLOGY AND THERAPEUTICS | 1995年 / 33卷 / 11期

关键词：

SPARFLOXACIN; CIMETIDINE; PHARMACOKINETICS; DRUG INTERACTION;

D O I：

暂无

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The interaction between cimetidine and sparfloxacin was studied in 10 healthy volunteers who received a single oral dose of 400 mg sparfloxacin on the third day of an 8 day cimetidine (400 mg t.i.d.) or placebo randomly assigned treatment. No statistically significant differences were observed in the pharmacokinetic parameters (C-max - AUC - T-1/2 - urinary excretion and metabolic ratio) of sparfloxacin following the 2 treatment. Cimetidine does not affect absorption, metabolism or urinary excretion of sparfloxacin; consequently, patients exposed to this drug combination are not at risk.

引用

页码：585 / 587

页数：3

共 50 条

[41] Sitagliptin, an dipeptidyl peptidase-4 inhibitor, does not alter the pharmacokinetics of the sulphonylurea, glyburide, in healthy subjects
Mistry, Goutam C.
Bergman, Arthur J.
Zheng, Wei
Hreniuk, David
Zinny, Miguel A.
Gottesdiener, Keith M.
Wagner, John A.
Herman, Gary A.
Ruddy, Marcella
BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, 2008, 66 (01) : 36 - 42
[42] Repeated administration of the novel antiepileptic agent levetiracetam does not alter digoxin pharmacokinetics and pharmacodynamics in healthy volunteers
Levy, RH
Ragueneau-Majlessi, I
Baltes, E
EPILEPSY RESEARCH, 2001, 46 (02) : 93 - 99
[43] LACK OF EFFECT OF OMEPRAZOLE, CIMETIDINE, AND RANITIDINE ON THE PHARMACOKINETICS OF ETHANOL IN FASTING MALE-VOLUNTEERS
JONSSON, KA
JONES, AW
BOSTROM, H
ANDERSSON, T
EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY, 1992, 42 (02) : 209 - 212
[44] Effect of cimetidine, a model drug for inhibition of the organic cation transport (OCT2/MATE1) in the kidney, on the pharmacokinetics of glycopyrronium
Dumitras, Swati
Sechaud, Romain
Drollmann, Anton
Pal, Parasar
Vaidyanathan, Sivakumar
Camenisch, Gian
Kaiser, Guenther
INTERNATIONAL JOURNAL OF CLINICAL PHARMACOLOGY AND THERAPEUTICS, 2013, 51 (10) : 771 - 779
[45] Effects of rifampicin and cimetidine on pharmacokinetics and pharmacodynamics of lamotrigine in healthy subjects
Ebert, U
Thong, NQ
Oertel, R
Kirch, W
EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY, 2000, 56 (04) : 299 - 304
[46] PHARMACOKINETICS OF ETODOLAC ENANTIOMERS IN THE RAT AFTER ADMINISTRATION OF PHENOBARBITAL OR CIMETIDINE
BROCKS, DR
JAMALI, F
EUROPEAN JOURNAL OF DRUG METABOLISM AND PHARMACOKINETICS, 1992, 17 (04) : 293 - 299
[47] Effects of probenecid and cimetidine on the pharmacokinetics of nemonoxacin in healthy Chinese volunteers
Zhang, Yi-fan
Dai, Xiao-jian
Yang, Yong
Chen, Xiao-yan
Wang, Ting
Tang, Yun-biao
Tsai, Cheng-yuan
Chang, Li-wen
Chang, Yu-ting
Zhong, Da-fang
DRUG DESIGN DEVELOPMENT AND THERAPY, 2016, 10 : 357 - 370
[48] Ketobemidone may alter busulfan pharmacokinetics during high-dose therapy
Hassan, M
Svensson, JO
Nilsson, C
Hentschke, P
AL-Shurbaji, A
Aschan, J
Ljungman, P
Ringdén, O
THERAPEUTIC DRUG MONITORING, 2000, 22 (04) : 383 - 385
[49] EFFECTS OF CIMETIDINE ON PHARMACOKINETICS AND PHARMACODYNAMICS OF IOSARTAN, AN AT(1)-SELECTIVE NONPEPTIDE ANGIOTENSIN-II RECEPTOR ANTAGONIST
GOLDBERG, MR
LO, MW
BRADSTREET, TE
RITTER, MA
HOGLUND, P
EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY, 1995, 49 (1-2) : 115 - 119
[50] INFLUENCE OF THE H-2-RECEPTOR ANTAGONISTS CIMETIDINE AND RANITIDINE ON THE PHARMACOKINETICS OF NIMODIPINE IN HEALTHY-VOLUNTEERS
MUCK, W
WINGENDER, W
SEIBERLING, M
WOELKE, E
RAMSCH, KD
KUHLMANN, J
EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY, 1992, 42 (03) : 325 - 328

← 1 2 3 4 5 →