CYSTIC-FIBROSIS HETEROZYGOTE RESISTANCE TO CHOLERA-TOXIN IN THE CYSTIC-FIBROSIS MOUSE MODEL

被引：353
作者：
GABRIEL, SE
BRIGMAN, KN
KOLLER, BH
BOUCHER, RC
STUTTS, MJ
机构：
[1] Department of Medicine, University of North Carolina, Chapel Hill
来源：
SCIENCE | 1994年 / 266卷 / 5182期
关键词：
D O I：
10.1126/science.7524148
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
The effect of the number of cystic fibrosis (CF) alleles on cholera toxin (CT)-induced intestinal secretion was examined in the CF mouse model. CF mice that expressed no CF transmembrane conductance regulator (CFTR) protein did not secrete fluid in response to CT. Heterozygotes expressed 50 percent of the normal amount of CFTR protein in the intestinal epithelium and secreted 50 percent of the normal fluid and chloride ion in response to CT. This correlation between CFTR protein and CT-induced chloride ion and fluid secretion suggests that CF heterozygotes might possess a selective advantage of resistance to cholera.
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页码：107 / 109
页数：3
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